Idioma:

NMDA and non-NMDA receptors are co-localized at individual excitatory synapses in cultured rat hippocampus

Bekkers, John M ; Stevens, Charles F

Nature (London), 1989-09, Vol.341 (6239), p.230-233 [Periódico revisado por pares]

London: Nature Publishing

Texto completo disponível

Citações Citado por

Enviar para

Título:
NMDA and non-NMDA receptors are co-localized at individual excitatory synapses in cultured rat hippocampus
Autor: Bekkers, John M ; Stevens, Charles F
Assuntos: Action Potentials - drug effects ; Anatomy & physiology ; Animals ; Aspartic Acid - analogs & derivatives ; Aspartic Acid - physiology ; Biochemistry ; Biological and medical sciences ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Electric Conductivity ; Fundamental and applied biological sciences. Psychology ; Glutamates - physiology ; hippocampus ; Hippocampus (Brain) ; Hippocampus - physiology ; Methyl aspartate ; N-Methylaspartate ; Neurotransmitter Agents - physiology ; Rats ; Receptors, Glutamate ; Receptors, N-Methyl-D-Aspartate ; Receptors, Neurotransmitter - physiology ; Rodents ; Synapses ; Synapses - physiology ; Synapses - ultrastructure ; Synaptic Transmission ; Tetrodotoxin - pharmacology ; Vertebrates: nervous system and sense organs
É parte de: Nature (London), 1989-09, Vol.341 (6239), p.230-233
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
Descrição: A CENTRAL assumption about long-term potentiation in the hippocampus is that the two classes of glutamate-receptor ion channel, the N-methyl-D-aspartate (NMDA) and the kainate/quisqualate (non-NMDA) subtypes, are co-localized at individual excitatory synapses. This assumption is important because of the perceived interplay between NMDA and non-NMDA receptors in the induction and expression of long-term potentiation: the NMDA class, by virtue of its voltage-dependent channel block by magnesium and calcium permeability, provides the trigger for the induction of long-term potentiation, whereas the actual enhancement of synaptic efficacy is thought to be provided by the non-NMDA class. If both receptor subtypes are present at the one synapse, such cross-modulation could occur rapidly and locally through diffusible factors. By measuring miniature synaptic currents in cultured hippocampal neurons we show that the majority (approximately 70%) of the excitatory synapses on a postsynaptic cell possess both kinds of receptor, although to different extents. Of the remaining excitatory synapses, approximately 20% contain only the non-NMDA subtype and the rest possess only NMDA receptors. This finding provides direct evidence for co-localization of glutamate-receptor subtypes at individual synapses, and also points to the possibility that long-term potentiation might be differentially expressed at each synapse according to the mix of receptor subtypes at that synapse.
Editor: London: Nature Publishing
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

NMDA and non-NMDA receptors are co-localized at individual excitatory synapses in cultured rat hippocampus

Bekkers, John M ; Stevens, Charles F

London: Nature Publishing

Buscando em bases de dados remotas. Favor aguardar.