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Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia

Kenter, Gemma G ; Welters, Marij J.P ; Valentijn, A. Rob P.M ; Lowik, Margriet J.G ; Berends-van der Meer, Dorien M.A ; Vloon, Annelies P.G ; Essahsah, Farah ; Fathers, Lorraine M ; Offringa, Rienk ; Drijfhout, Jan Wouter ; Wafelman, Amon R ; Oostendorp, Jaap ; Fleuren, Gert Jan ; van der Burg, Sjoerd H ; Melief, Cornelis J.M

The New England journal of medicine, 2009-11, Vol.361 (19), p.1838-1847 [Periódico revisado por pares]

Waltham, MA: Massachusetts Medical Society

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Título:
Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia
Autor: Kenter, Gemma G ; Welters, Marij J.P ; Valentijn, A. Rob P.M ; Lowik, Margriet J.G ; Berends-van der Meer, Dorien M.A ; Vloon, Annelies P.G ; Essahsah, Farah ; Fathers, Lorraine M ; Offringa, Rienk ; Drijfhout, Jan Wouter ; Wafelman, Amon R ; Oostendorp, Jaap ; Fleuren, Gert Jan ; van der Burg, Sjoerd H ; Melief, Cornelis J.M
Assuntos: Adult ; Biological and medical sciences ; Cancer Vaccines - adverse effects ; Cancer Vaccines - immunology ; Cancer Vaccines - therapeutic use ; Carcinoma in Situ - therapy ; Carcinoma in Situ - virology ; Cervical cancer ; Female ; Female genital diseases ; Freund's Adjuvant ; General aspects ; Gynecology. Andrology. Obstetrics ; Health aspects ; Human papillomavirus ; Human papillomavirus 16 - immunology ; Human papillomavirus 16 - isolation & purification ; Humans ; Medical research ; Medical sciences ; Middle Aged ; Oncogene Proteins, Viral - immunology ; Papillomavirus E7 Proteins ; Papillomavirus infections ; Papillomavirus Infections - complications ; Papillomavirus Infections - immunology ; Papillomavirus Infections - therapy ; Papillomavirus Vaccines - adverse effects ; Papillomavirus Vaccines - immunology ; Papillomavirus Vaccines - therapeutic use ; Prevention ; Prevention and actions ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Repressor Proteins - immunology ; T-Lymphocytes - immunology ; Treatment Outcome ; Tumors ; Vaccination ; Vaccines ; Vaccines, Synthetic ; Vulvar diseases ; Vulvar Neoplasms - therapy ; Vulvar Neoplasms - virology ; Young Adult
É parte de: The New England journal of medicine, 2009-11, Vol.361 (19), p.1838-1847
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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Descrição: In this single-group study involving women with grade 3 vulvar intraepithelial neoplasia associated with human papillomavirus type 16 (HPV-16), vaccination against HPV-16 infection with a peptide vaccine was related to a clinical response in 15 of 19 patients (79%) at 1 year. This clinical response was associated with induction of HPV-16–specific T cells. In women with grade 3 vulvar intraepithelial neoplasia associated with human papillomavirus type 16, vaccination against HPV-16 infection with a peptide vaccine was related to a clinical response in 79% of patients at 1 year. Vulvar intraepithelial neoplasia is a chronic premalignant disorder of the vulvar skin that is caused by high-risk types of human papillomavirus (HPV); HPV type 16 (HPV-16) is involved in more than 75% of cases. 1 – 5 Spontaneous regression occurs in less than 1.5% of patients, and the rate of recurrence after surgical treatment is high. 6 Expression of the viral oncoproteins E6 and E7 contributes to the development of these genital lesions and their progression to invasive carcinoma. 6 , 7 Virus-specific, interferon-γ–producing CD4+ T cells and CD8+ cytotoxic T lymphocytes are essential components in controlling chronic viral infections. 8 , 9 In the blood of . . .
Editor: Waltham, MA: Massachusetts Medical Society
Idioma: Inglês

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Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia

Waltham, MA: Massachusetts Medical Society

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