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Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue

Marletta, Michael A ; Bargmann, Cornelia I ; Gray, Jesse M ; Karow, David S ; Lu, Hang ; Chang, Andy J ; Chang, Jennifer S ; Ellis, Ronald E

Nature, 2004-07, Vol.430 (6997), p.317-322 [Periódico revisado por pares]

London: Nature Publishing

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Título:
Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue
Autor: Marletta, Michael A ; Bargmann, Cornelia I ; Gray, Jesse M ; Karow, David S ; Lu, Hang ; Chang, Andy J ; Chang, Jennifer S ; Ellis, Ronald E
Assuntos: Animal and plant ecology ; Animal behavior ; Animal, plant and microbial ecology ; Animals ; Autoecology ; Bacteria - genetics ; Bacteria - metabolism ; Biochemistry. Physiology. Immunology. Molecular biology ; Biological and medical sciences ; Caenorhabditis elegans ; Caenorhabditis elegans - drug effects ; Caenorhabditis elegans - enzymology ; Caenorhabditis elegans - genetics ; Caenorhabditis elegans - physiology ; Caenorhabditis elegans Proteins - chemistry ; Caenorhabditis elegans Proteins - genetics ; Caenorhabditis elegans Proteins - metabolism ; Cell Aggregation - drug effects ; Cyclic GMP - metabolism ; Feeding Behavior - drug effects ; Feeding Behavior - physiology ; Food ; Fundamental and applied biological sciences. Psychology ; Gases - metabolism ; Guanylate Cyclase - chemistry ; Guanylate Cyclase - genetics ; Guanylate Cyclase - metabolism ; Heme - metabolism ; Hyperoxia - enzymology ; Hyperoxia - genetics ; Hyperoxia - metabolism ; Invertebrates ; Ion Channels - metabolism ; Molecular biology ; Mutation - genetics ; Nemathelminthia. Plathelmintha ; Neurons, Afferent - metabolism ; Nitric Oxide - metabolism ; Nitric Oxide - pharmacology ; Oxygen ; Oxygen - metabolism ; Oxygen - pharmacology ; Physiology. Development ; Protein Binding ; Protein Structure, Tertiary ; Protozoa. Invertebrata ; Social Behavior ; Worms
É parte de: Nature, 2004-07, Vol.430 (6997), p.317-322
Notas: ObjectType-Article-2
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Descrição: Specialized oxygen-sensing cells in the nervous system generate rapid behavioural responses to oxygen. We show here that the nematode Caenorhabditis elegans exhibits a strong behavioural preference for 5-12% oxygen, avoiding higher and lower oxygen levels. 3',5'-cyclic guanosine monophosphate (cGMP) is a common second messenger in sensory transduction and is implicated in oxygen sensation. Avoidance of high oxygen levels by C. elegans requires the sensory cGMP-gated channel tax-2/tax-4 and a specific soluble guanylate cyclase homologue, gcy-35. The GCY-35 haem domain binds molecular oxygen, unlike the haem domains of classical nitric-oxide-regulated guanylate cyclases. GCY-35 and TAX-4 mediate oxygen sensation in four sensory neurons that control a naturally polymorphic social feeding behaviour in C. elegans. Social feeding and related behaviours occur only when oxygen exceeds C. elegans' preferred level, and require gcy-35 activity. Our results suggest that GCY-35 is regulated by molecular oxygen, and that social feeding can be a behavioural strategy for responding to hyperoxic environments.
Editor: London: Nature Publishing
Idioma: Inglês

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Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue

Marletta, Michael A ; Bargmann, Cornelia I ; Gray, Jesse M ; Karow, David S ; Lu, Hang ; Chang, Andy J ; Chang, Jennifer S ; Ellis, Ronald E

London: Nature Publishing

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