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Proteomics of calcium-signaling components in plants

Reddy, Vaka S. ; Reddy, Anireddy S.N.

Phytochemistry (Oxford), 2004-06, Vol.65 (12), p.1745-1776 [Periódico revisado por pares]

England: Elsevier Ltd

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Título:
Proteomics of calcium-signaling components in plants
Autor: Reddy, Vaka S. ; Reddy, Anireddy S.N.
Assuntos: adenosinetriphosphatase ; antiporters ; Arabidopsis - genetics ; Arabidopsis - metabolism ; Arabidopsis thaliana ; Bioinformatics ; Ca(2+)-transporting ATPase ; Ca2+-binding proteins ; Calcium ; calcium channels ; Calcium Signaling ; Calmodulin ; Calmodulin-binding proteins ; DNA-binding proteins ; enzyme substrates ; literature reviews ; Mass spectrometry ; Microarray, SELEX, ChIP, Tandom affinity purification ; Models, Biological ; molecular genetics ; plant proteins ; Plant Proteins - analysis ; Plant Proteins - isolation & purification ; Plants - metabolism ; Protein Binding ; protein kinases ; protein-protein interactions ; Proteome ; Proteome - analysis ; Proteomics ; Signal Transduction ; Signaling
É parte de: Phytochemistry (Oxford), 2004-06, Vol.65 (12), p.1745-1776
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Descrição: Calcium functions as a versatile messenger in mediating responses to hormones, biotic/abiotic stress signals and a variety of developmental cues in plants. Calcium circuitry consists of at least three major nodes. The components of each node and their functions are discussed. An overview of genome-wide approaches in unraveling Ca2+-signaling circuitry is presented. Calcium functions as a versatile messenger in mediating responses to hormones, biotic/abiotic stress signals and a variety of developmental cues in plants. The Ca2+-signaling circuit consists of three major “nodes” – generation of a Ca2+-signature in response to a signal, recognition of the signature by Ca2+ sensors and transduction of the signature message to targets that participate in producing signal-specific responses. Molecular genetic and protein–protein interaction approaches together with bioinformatic analysis of the Arabidopsis genome have resulted in identification of a large number of proteins at each “node” – ∼80 at Ca2+ signature, ∼400 sensors and ∼200 targets – that form a myriad of Ca2+ signaling networks in a “mix and match” fashion. In parallel, biochemical, cell biological, genetic and transgenic approaches have unraveled functions and regulatory mechanisms of a few of these components. The emerging paradigm from these studies is that plants have many unique Ca2+ signaling proteins. The presence of a large number of proteins, including several families, at each “node” and potential interaction of several targets by a sensor or vice versa are likely to generate highly complex networks that regulate Ca2+-mediated processes. Therefore, there is a great demand for high-throughput technologies for identification of signaling networks in the “Ca2+-signaling-grid” and their roles in cellular processes. Here we discuss the current status of Ca2+ signaling components, their known functions and potential of emerging high-throughput genomic and proteomic technologies in unraveling complex Ca2+ circuitry.
Editor: England: Elsevier Ltd
Idioma: Inglês

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Proteomics of calcium-signaling components in plants

Reddy, Vaka S. ; Reddy, Anireddy S.N.

England: Elsevier Ltd

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