skip to main content
Idioma:
Tipo de recurso Mostra resultados com: Mostra resultados com: Índice

The Role of 3'-5' Exoribonucleases in RNA Degradation

Andrade, José M ; Pobre, Vânia ; Silva, Inês J ; Domingues, Susana ; Arraiano, Cecília M

Molecular Biology of RNA Processing and Decay in Prokaryotes, 2009, Vol.85, p.187-229 [Periódico revisado por pares]

United States: Elsevier Science & Technology

Texto completo disponível

Citações Citado por
  • Título:
    The Role of 3'-5' Exoribonucleases in RNA Degradation
  • Autor: Andrade, José M ; Pobre, Vânia ; Silva, Inês J ; Domingues, Susana ; Arraiano, Cecília M
  • Assuntos: Base Sequence ; Escherichia coli - enzymology ; Exoribonucleases - metabolism ; MEDICINE ; Molecular biology ; Molecular Sequence Data ; Polyribonucleotide Nucleotidyltransferase - metabolism ; RNA Stability
  • É parte de: Molecular Biology of RNA Processing and Decay in Prokaryotes, 2009, Vol.85, p.187-229
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: RNA degradation is a major process controlling RNA levels and plays a central role in cell metabolism. From the labile messenger RNA to the more stable noncoding RNAs (mostly rRNA and tRNA, but also the expanding class of small regulatory RNAs) all molecules are eventually degraded. Elimination of superfluous transcripts includes RNAs whose expression is no longer required, but also the removal of defective RNAs. Consequently, RNA degradation is an inherent step in RNA quality control mechanisms. Furthermore, it contributes to the recycling of the nucleotide pool in the cell. Escherichia coli has eight 3'-5' exoribonucleases, which are involved in multiple RNA metabolic pathways. However, only four exoribonucleases appear to accomplish all RNA degradative activities: polynucleotide phosphorylase (PNPase), ribonuclease II (RNase II), RNase R, and oligoribonuclease. Here, we summarize the available information on the role of bacterial 3'-5' exoribonucleases in the degradation of different substrates, highlighting the most recent data that have contributed to the understanding of the diverse modes of operation of these degradative enzymes.
  • Editor: United States: Elsevier Science & Technology
  • Idioma: Inglês
Links
Voltar para lista de resultados
Resultado  1 AvançarIr para próxima página

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.