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The Impact of Transplantation with Deceased Donor Hepatitis C‐Positive Kidneys on Survival in Wait‐Listed Long‐term Dialysis Patients

Abbott, Kevin C. ; Lentine, Krista L. ; Bucci, Jay R. ; Agodoa, Lawrence Y. ; Peters, Thomas G. ; Schnitzler, Mark A.

American journal of transplantation, 2004-12, Vol.4 (12), p.2032-2037 [Periódico revisado por pares]

9600 Garsington Road , Oxford , OX4 2DQ , UK: Munksgaard International Publishers

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Título:
The Impact of Transplantation with Deceased Donor Hepatitis C‐Positive Kidneys on Survival in Wait‐Listed Long‐term Dialysis Patients
Autor: Abbott, Kevin C. ; Lentine, Krista L. ; Bucci, Jay R. ; Agodoa, Lawrence Y. ; Peters, Thomas G. ; Schnitzler, Mark A.
Assuntos: Aged ; Black ; Databases, Factual ; deceased donor ; dialysis ; donor ; elderly ; end‐stage renal disease ; expanded criteria donor ; hepatitis C ; Hepatitis C - transmission ; Humans ; Kidney Failure, Chronic - surgery ; kidney transplant ; Kidney Transplantation - mortality ; Kidney Transplantation - statistics & numerical data ; Medicare ; survival ; Survival Analysis ; Tissue Donors - statistics & numerical data ; Tissue Donors - supply & distribution ; Treatment Outcome ; United States ; USRDS ; wait list ; Waiting Lists
É parte de: American journal of transplantation, 2004-12, Vol.4 (12), p.2032-2037
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Whether transplantation of deceased donor kidney allografts from donors with antibodies against hepatitis C virus (HCV) confers a survival advantage compared with remaining on the kidney transplant waiting list is not yet known. We studied 38,270 USRDS Medicare beneficiaries awaiting kidney transplantation who presented with end‐stage renal disease from April 1, 1995 to July 31, 2000. Cox regression was used to compare the adjusted hazard ratios for death among recipients of kidneys from deceased donors, and donors with antibodies against hepatitis C (DHCV+), controlling for demographics and comorbidities. In comparison to staying on the waiting list, transplantation from DHCV+ was associated with improved survival among all patients (adjusted hazard ratio for death 0.76, 95% CI 0.60, 0.96). Of patients receiving DHCV+ kidneys, 52% were themselves hepatitis C antibody positive (HCV+), so outcomes associated with use of these grafts may have particular implications for HCV+ transplant candidates. Recommendations for use of DHCV+ kidneys may require analysis of data not currently collected from either dialysis or transplant patients. However, transplantation of DHCV+ kidneys is associated with improved patient survival compared to remaining wait‐listed and dialysis dependent.
Editor: 9600 Garsington Road , Oxford , OX4 2DQ , UK: Munksgaard International Publishers
Idioma: Inglês

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The Impact of Transplantation with Deceased Donor Hepatitis C‐Positive Kidneys on Survival in Wait‐Listed Long‐term Dialysis Patients

Abbott, Kevin C. ; Lentine, Krista L. ; Bucci, Jay R. ; Agodoa, Lawrence Y. ; Peters, Thomas G. ; Schnitzler, Mark A.

9600 Garsington Road , Oxford , OX4 2DQ , UK: Munksgaard International Publishers

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