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Oxidative state in platelets and erythrocytes in aging and Alzheimer's disease

Kawamoto, Elisa Mitiko ; Munhoz, Carolina Demarchi ; Glezer, Isaias ; Bahia, Valéria Santoro ; Caramelli, Paulo ; Nitrini, Ricardo ; Gorjão, Renata ; Curi, Rui ; Scavone, Cristoforo ; Marcourakis, Tania

Neurobiology of aging, 2005-06, Vol.26 (6), p.857-864 [Periódico revisado por pares]

London: Elsevier Inc

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Título:
Oxidative state in platelets and erythrocytes in aging and Alzheimer's disease
Autor: Kawamoto, Elisa Mitiko ; Munhoz, Carolina Demarchi ; Glezer, Isaias ; Bahia, Valéria Santoro ; Caramelli, Paulo ; Nitrini, Ricardo ; Gorjão, Renata ; Curi, Rui ; Scavone, Cristoforo ; Marcourakis, Tania
Assuntos: Aged ; Aged, 80 and over ; Aging ; Aging - metabolism ; Alzheimer Disease - blood ; Alzheimer Disease - pathology ; Alzheimer's disease ; Biological and medical sciences ; Blood Platelets - metabolism ; Cyclic GMP ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Erythrocytes ; Erythrocytes - metabolism ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Na,K-ATPase ; Neurology ; Nitric oxide ; Oxidative Stress ; Oxygen - blood ; Platelets ; Reactive Oxygen Species - blood ; SOD ; TBARS
É parte de: Neurobiology of aging, 2005-06, Vol.26 (6), p.857-864
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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Descrição: Several studies have shown involvement of peroxynitrite anion, a potent oxidative agent, in Alzheimer's disease (AD) neuropathology. Herein, we assessed in platelets and erythrocytes of AD patients, age-matched and young adults controls: thiobarbituric acid-reactive substances (TBARS) production; superoxide dismutase (SOD), nitric oxide synthase (NOS) and Na,K-ATPase activities; cyclic GMP (cGMP) content, both basal and after sodium nitroprusside (SNP) stimulation. Aging was associated with an increase in TBARS production and NOS activity, a decrease in basal cGMP content and no change in SOD and Na,K-ATPase activities. AD patients, compared to aged controls, have: increase in TBARS production and in NOS, SOD and Na,K-ATPase activities but no alteration in basal cGMP content. SNP increased cGMP platelets production in all groups. In conclusion, we demonstrated in platelets and erythrocytes a disruption in systemic modulation of oxidative stress in aging and with more intensity in AD.
Editor: London: Elsevier Inc
Idioma: Inglês

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Oxidative state in platelets and erythrocytes in aging and Alzheimer's disease

Kawamoto, Elisa Mitiko ; Munhoz, Carolina Demarchi ; Glezer, Isaias ; Bahia, Valéria Santoro ; Caramelli, Paulo ; Nitrini, Ricardo ; Gorjão, Renata ; Curi, Rui ; Scavone, Cristoforo ; Marcourakis, Tania

London: Elsevier Inc

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