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The invertor knock-in conditional chromosomal translocation mimic

Rabbitts, Terence H ; Forster, Alan ; Pannell, Richard ; Drynan, Lesley F ; Codrington, Rosalind ; Daser, Angelika ; Metzler, Markus ; Lobato, M Natividad

Nature methods, 2005-01, Vol.2 (1), p.27-30 [Periódico revisado por pares]

United States: Nature Publishing Group

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The invertor knock-in conditional chromosomal translocation mimic
Autor: Rabbitts, Terence H ; Forster, Alan ; Pannell, Richard ; Drynan, Lesley F ; Codrington, Rosalind ; Daser, Angelika ; Metzler, Markus ; Lobato, M Natividad
Assuntos: Alleles ; Animals ; Base Sequence ; Cancer ; Cell Separation ; Chromosome abnormalities ; Chromosomes - ultrastructure ; Diagnosis ; DNA testing ; DNA, Complementary - metabolism ; Flow Cytometry ; Genetic aspects ; Genetic Techniques ; Humans ; Introns ; Methods ; Mice ; Mice, Inbred C57BL ; Models, Genetic ; Molecular Sequence Data ; Mutation ; Recombination, Genetic ; Reverse Transcriptase Polymerase Chain Reaction ; RNA - metabolism ; Transcription, Genetic ; Translocation, Genetic
É parte de: Nature methods, 2005-01, Vol.2 (1), p.27-30
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Knock-in models of tumor-specific chromosomal translocations can generate lethal mutations. To circumvent this, a new conditional gene fusion model has been developed (invertor mice) and exemplified with the Ews-ERG fusion oncogene. An ERG segment, flanked by loxP sites, was knocked in to an intron of the Ews gene but in an inverted transcription orientation and lineage-specific Ews-ERG fusion created by Cre-mediated inversion. This invertor method is a completely conditional approach, applicable to any gene fusion, to emulate effects of translocations found in human cancers.
Editor: United States: Nature Publishing Group
Idioma: Inglês

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The invertor knock-in conditional chromosomal translocation mimic

Rabbitts, Terence H ; Forster, Alan ; Pannell, Richard ; Drynan, Lesley F ; Codrington, Rosalind ; Daser, Angelika ; Metzler, Markus ; Lobato, M Natividad

United States: Nature Publishing Group

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