Idioma:

Clinical Examination Following Preoperative Chemoradiation for Rectal Cancer Is Not a Reliable Surrogate End Point

GUILLEM, Jose G ; CHESSIN, David B ; TEMPLE, Larissa K. F ; COHEN, Alfred M ; WONG, W. Douglas ; SHIA, Jinru ; MOORE, Harvey G ; MAZUMDAR, Madhu ; BERNARD, Bianca ; PATY, Philip B ; SALTZ, Leonard ; MINSKY, Bruce D ; WEISER, Martin R

Journal of clinical oncology, 2005-05, Vol.23 (15), p.3475-3479 [Periódico revisado por pares]

Baltimore, MD: American Society of Clinical Oncology

Sem texto completo

Citações Citado por

Enviar para

Título:
Clinical Examination Following Preoperative Chemoradiation for Rectal Cancer Is Not a Reliable Surrogate End Point
Autor: GUILLEM, Jose G ; CHESSIN, David B ; TEMPLE, Larissa K. F ; COHEN, Alfred M ; WONG, W. Douglas ; SHIA, Jinru ; MOORE, Harvey G ; MAZUMDAR, Madhu ; BERNARD, Bianca ; PATY, Philip B ; SALTZ, Leonard ; MINSKY, Bruce D ; WEISER, Martin R
Assuntos: Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Chemotherapy, Adjuvant ; Cohort Studies ; Colectomy - methods ; Combined Modality Therapy ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Neoplasm Staging ; Palpation ; Physical Examination - methods ; Preoperative Care - methods ; Prognosis ; Prospective Studies ; Radiotherapy, Adjuvant ; Rectal Neoplasms - diagnosis ; Rectal Neoplasms - mortality ; Rectal Neoplasms - therapy ; Risk Assessment ; Sensitivity and Specificity ; Survival Rate ; Treatment Outcome ; Tumors
É parte de: Journal of clinical oncology, 2005-05, Vol.23 (15), p.3475-3479
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Clinical assessment of rectal cancer response to preoperative combined-modality therapy (CMT) using digital rectal examination (DRE) has been proposed as a means of assessing efficacy of therapy. However, because the accuracy of this approach has not been established, we conducted a prospective analysis to determine the operating surgeon's ability to assess response using DRE. Ninety-four prospectively accrued patients with locally advanced rectal cancer (T3/4 or N1) were evaluated with DRE and sigmoidoscopy in order to determine the following tumor characteristics: size, location, mobility, morphology, and circumference. Following preoperative CMT (50.40 Gy with fluorouracil-based chemotherapy) and under general anesthesia, the same surgeon estimated tumor response based on changes in these tumor characteristics, assessed via DRE. Percent pathologic tumor response was determined prospectively by a single pathologist using whole mount sections of the resected cancer. Clinical assessment using DRE underestimated pathologic response in 73 cases (78%). In addition, DRE was able to identify only 3 of 14 cases (21%) with a pathologic complete response. There were no clinical overestimates of response. None of the clinicopathologic tumor characteristics examined had a significant impact on DRE estimation of response. Clinical examination underestimates the extent of rectal cancer response to preoperative CMT. Given the inaccuracy of DRE following preoperative CMT, it should not be used as a sole means of assessing efficacy of therapy nor for selecting patients following CMT for local surgical therapies.
Editor: Baltimore, MD: American Society of Clinical Oncology
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Clinical Examination Following Preoperative Chemoradiation for Rectal Cancer Is Not a Reliable Surrogate End Point

GUILLEM, Jose G ; CHESSIN, David B ; TEMPLE, Larissa K. F ; COHEN, Alfred M ; WONG, W. Douglas ; SHIA, Jinru ; MOORE, Harvey G ; MAZUMDAR, Madhu ; BERNARD, Bianca ; PATY, Philip B ; SALTZ, Leonard ; MINSKY, Bruce D ; WEISER, Martin R

Baltimore, MD: American Society of Clinical Oncology

Buscando em bases de dados remotas. Favor aguardar.