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Migratory Langerhans Cells in Mouse Lymph Nodes in Steady State and Inflammation

Stoitzner, Patrizia ; Tripp, Christoph H. ; Douillard, Patrice ; Saeland, Sem ; Romani, Nikolaus

Journal of investigative dermatology, 2005-07, Vol.125 (1), p.116-125 [Periódico revisado por pares]

Danvers, MA: Elsevier Inc

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Título:
Migratory Langerhans Cells in Mouse Lymph Nodes in Steady State and Inflammation
Autor: Stoitzner, Patrizia ; Tripp, Christoph H. ; Douillard, Patrice ; Saeland, Sem ; Romani, Nikolaus
Assuntos: Animals ; Antibodies, Monoclonal ; Antigens, CD - metabolism ; B7-1 Antigen - metabolism ; B7-2 Antigen ; Biological and medical sciences ; CD4-Positive T-Lymphocytes ; CD40 Antigens - metabolism ; cell surface molecules ; cytokines ; dendritic cells ; Dermatology ; Gene Expression ; In Vitro Techniques ; inflammation ; Inflammation - physiopathology ; Langerhans Cells - metabolism ; Lymph Nodes - metabolism ; Medical sciences ; Membrane Glycoproteins - metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; skin ; steady state
É parte de: Journal of investigative dermatology, 2005-07, Vol.125 (1), p.116-125
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Dendritic cells cells induce immunity or—in the steady state—maintain peripheral tolerance. Little is known in that regard about Langerhans cells. Therefore, we investigated migrating Langerhans cells in the steady-state versus inflammation. Increased numbers of Langerhans cells, as determined by immunostaining for Langerin/CD207, appeared in the lymph nodes in response to a contact allergen. Whereas a large proportion of Langerhans cells expressed CD86 in the steady state, CD40, and CD80 were found on a smaller percentage. During inflammation, more CD40+, CD80+, CD274/B7-H1/PD-L1+, and CD273/B7-DC/PD-L2+ Langerhans cells were found in the lymph nodes, and they expressed higher levels of these molecules. CD275/inducible T cell co-stimulator (ICOS) ligand was not detected. Langerhans cells in the nodes of contact allergen-treated mice produced more IL-12p40/70. This correlated with more interferon-γ being produced by activated lymph node T cells. Epicutaneous immunization with ovalbumin under inflammatory conditions led to a more vigorous proliferation of antigen-specific CD4 T cells in vitro and in vivo as compared with immunization in the steady state. The latter modality, however did not induce strong CD4 T cell tolerance in this model. Thus, the overall phenotype of Langerhans cells is not an indicator for their immunogenic or tolerogenic potential.
Editor: Danvers, MA: Elsevier Inc
Idioma: Inglês

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Migratory Langerhans Cells in Mouse Lymph Nodes in Steady State and Inflammation

Stoitzner, Patrizia ; Tripp, Christoph H. ; Douillard, Patrice ; Saeland, Sem ; Romani, Nikolaus

Danvers, MA: Elsevier Inc

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