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ADHD- and medication-related brain activation effects in concordantly affected parent-child dyads with ADHD

Epstein, Jeffery N. ; Casey, B.J. ; Tonev, Simon T. ; Davidson, Matthew C. ; Reiss, Allan L. ; Garrett, Amy ; Hinshaw, Stephen P. ; Greenhill, Laurence L. ; Glover, Gary ; Shafritz, Keith M. ; Vitolo, Alan ; Kotler, Lisa A. ; Jarrett, Matthew A. ; Spicer, Julie

Journal of child psychology and psychiatry, 2007-09, Vol.48 (9), p.899-913 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
ADHD- and medication-related brain activation effects in concordantly affected parent-child dyads with ADHD
Autor: Epstein, Jeffery N. ; Casey, B.J. ; Tonev, Simon T. ; Davidson, Matthew C. ; Reiss, Allan L. ; Garrett, Amy ; Hinshaw, Stephen P. ; Greenhill, Laurence L. ; Glover, Gary ; Shafritz, Keith M. ; Vitolo, Alan ; Kotler, Lisa A. ; Jarrett, Matthew A. ; Spicer, Julie
Assuntos: Abnormality ; ADHD ; adolescence ; Adult ; adulthood ; Adults ; Attention Deficit Disorder with Hyperactivity - drug therapy ; Attention Deficit Disorder with Hyperactivity - physiopathology ; Attention deficit disorders. Hyperactivity ; Attention Deficit Hyperactivity Disorder ; Biological and medical sciences ; Brain ; Brain - drug effects ; Brain - physiopathology ; brain imaging ; Central Nervous System Stimulants - pharmacology ; Central Nervous System Stimulants - therapeutic use ; Child ; Child clinical studies ; Child psychology ; Children ; Clinical trials ; development ; Double-Blind Method ; Drug therapy ; Female ; fMRI ; Genetic factors ; Genetics ; Humans ; Hyperactivity ; Magnetic Resonance Imaging ; Male ; Medical sciences ; methylphenidate ; Methylphenidate - pharmacology ; Methylphenidate - therapeutic use ; Neurobiological aspects ; Neurological Organization ; Neuropharmacology ; neuropsychology ; Neurosciences ; Parent-Child Relations ; Parents ; Pharmacology. Drug treatments ; Psychiatry ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychopharmacology ; Stimulants ; Stimuli
É parte de: Journal of child psychology and psychiatry, 2007-09, Vol.48 (9), p.899-913
Notas: istex:3B0011663B54B06E837B6B2BA1C78035ECBF41FB
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ArticleID:JCPP1761
Conflict of interest statement: No conflicts declared.
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Descrição: Background: Several studies have documented fronto‐striatal dysfunction in children and adolescents with attention deficit/hyperactivity disorder (ADHD) using response inhibition tasks. Our objective was to examine functional brain abnormalities among youths and adults with ADHD and to examine the relations between these neurobiological abnormalities and response to stimulant medication. Method: A group of concordantly diagnosed ADHD parent–child dyads was compared to a matched sample of normal parent–child dyads. In addition, ADHD dyads were administered double‐blind methylphenidate and placebo in a counterbalanced fashion over two consecutive days of testing. Frontostriatal function was measured using functional magnetic resonance imaging (fMRI) during performance of a go/no‐go task. Results: Youths and adults with ADHD showed attenuated activity in fronto‐striatal regions. In addition, adults with ADHD appeared to activate non‐fronto‐striatal regions more than normals. A stimulant medication trial showed that among youths, stimulant medication increased activation in fronto‐striatal and cerebellar regions. In adults with ADHD, increases in activation were observed in the striatum and cerebellum, but not in prefrontal regions. Conclusions: This study extends findings of fronto‐striatal dysfunction to adults with ADHD and highlights the importance of frontostriatal and frontocerebellar circuitry in this disorder, providing evidence of an endophenotype for examining the genetics of ADHD.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

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ADHD- and medication-related brain activation effects in concordantly affected parent-child dyads with ADHD

Epstein, Jeffery N. ; Casey, B.J. ; Tonev, Simon T. ; Davidson, Matthew C. ; Reiss, Allan L. ; Garrett, Amy ; Hinshaw, Stephen P. ; Greenhill, Laurence L. ; Glover, Gary ; Shafritz, Keith M. ; Vitolo, Alan ; Kotler, Lisa A. ; Jarrett, Matthew A. ; Spicer, Julie

Oxford, UK: Blackwell Publishing Ltd

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