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Melatonin expression in periodontal disease

Gómez-Moreno, G. ; Cutando-Soriano, A. ; Arana, C. ; Galindo, P. ; Bolaños, J. ; Acuña-Castroviejo, D. ; Wang, H.-L.

Journal of periodontal research, 2007-12, Vol.42 (6), p.536-540 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
Melatonin expression in periodontal disease
Autor: Gómez-Moreno, G. ; Cutando-Soriano, A. ; Arana, C. ; Galindo, P. ; Bolaños, J. ; Acuña-Castroviejo, D. ; Wang, H.-L.
Assuntos: Biological and medical sciences ; Case-Control Studies ; Dentistry ; Facial bones, jaws, teeth, parodontium: diseases, semeiology ; Female ; Flow Cytometry ; Humans ; Killer Cells, Natural ; Lymphocyte Count ; lymphocyte populations ; Male ; Medical sciences ; melatonin ; Melatonin - analysis ; Melatonin - blood ; Melatonin - physiology ; Middle Aged ; Otorhinolaryngology. Stomatology ; periodontal disease ; Periodontal Index ; Periodontitis - blood ; Periodontitis - metabolism ; Salivary Proteins and Peptides - analysis
É parte de: Journal of periodontal research, 2007-12, Vol.42 (6), p.536-540
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Descrição: Background and Objective: It was the purpose of this study to examine the relationship between periodontal diseases and melatonin level. Material and Methods: Forty‐six patients with periodontal disease, together with 26 age‐ and gender‐matched healthy controls, were included. Periodontal status was assessed using the Community Periodontal Index. Plasma and salivary melatonin levels were determined using specific commercial radioimmunoassays, whereas lymphocyte subpopulations (e.g. CD3, CD4, CD8, C19 and natural killer cells) were analyzed using flow cytometry. Results: Patients with periodontal disease had significantly (p < 0.001) lower plasma (9.46 ± 3.18 pg/mL) and saliva (2.55 ± 0.99 pg/mL) melatonin levels than healthy control patients (14.33 ± 4.05 and 4.22 ± 0.87 pg/mL, respectively). A biphasic relationhip was observed between plasma melatonin levels and Community Periodontal Indices. The plasma melatonin level was reduced in patients with a lower Community Periodontal Index value (1 or 2) and increased in patients with a higher Community Periodontal Index value (3 or 4). Salivary melatonin parallels the changes of plasma melatonin. The higher the Community Periodontal Index, the older the patient and the higher the total lymphocyte counts. CD4 concentrations also increased as the disease worsened. Conclusion: The results obtained from this study suggest that melatonin could act as a protective function in fighting periodontal infection. However, further studies in this area are encouraged.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

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Melatonin expression in periodontal disease

Gómez-Moreno, G. ; Cutando-Soriano, A. ; Arana, C. ; Galindo, P. ; Bolaños, J. ; Acuña-Castroviejo, D. ; Wang, H.-L.

Oxford, UK: Blackwell Publishing Ltd

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