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Detection of human herpesvirus 8 (HHV-8) in normal prostates

Montgomery, J.D. ; Jacobson, L.P. ; Dhir, R. ; Jenkins, F.J.

The Prostate, 2006-09, Vol.66 (12), p.1302-1310 [Periódico revisado por pares]

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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Título:
Detection of human herpesvirus 8 (HHV-8) in normal prostates
Autor: Montgomery, J.D. ; Jacobson, L.P. ; Dhir, R. ; Jenkins, F.J.
Assuntos: Adult ; AIDS-Related Opportunistic Infections - metabolism ; Antigens, CD - metabolism ; Antigens, CD20 - metabolism ; Antigens, Differentiation, Myelomonocytic - metabolism ; Antigens, Viral - metabolism ; Biological and medical sciences ; chronic inflammation ; Gene Expression Profiling ; Gene Expression Regulation, Viral ; Glycoproteins - metabolism ; Gynecology. Andrology. Obstetrics ; Herpesviridae Infections - immunology ; Herpesviridae Infections - metabolism ; Herpesviridae Infections - pathology ; Herpesvirus 8, Human - metabolism ; HHV-8 ; Humans ; IHC ; Immunohistochemistry ; Inflammation ; Interleukin-6 - metabolism ; KSHV ; Male ; Male genital diseases ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Nuclear Proteins - metabolism ; Prostate - metabolism ; Prostate - pathology ; Prostate - virology ; prostate cancer ; Prostatic Diseases - immunology ; Prostatic Diseases - metabolism ; Prostatic Diseases - virology ; Tumors ; Tumors of the urinary system ; Urinary tract. Prostate gland ; Viral Proteins - metabolism
É parte de: The Prostate, 2006-09, Vol.66 (12), p.1302-1310
Notas: J. D. Montgomery is a Graduate Student, L. P. Jacobson, R. Dhir, and F. J. Jenkins are Associate Professors.
Anna E McElhany Fund
R. Green Annan Medical Fund
Simeon M. Jones, Jr. and Katharine Reed Jones Fund of the Pittsburgh Foundation
ark:/67375/WNG-GNX9C4CT-Q
University of Pittsburgh Cancer Institute Funds
istex:BF56C393E83F8E0C5A60C41AC4825A20BB397506
ArticleID:PROS20459
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: BACKGROUND Human herpesvirus 8 (HHV‐8) DNA has been detected in semen and prostatic tissues in some, but not all reports. We have analyzed prostate tissues from HHV‐8 seropositive men for the expression of viral proteins and determined if expression of these proteins are associated with increased inflammation. METHODS Paraffin sections of non‐cancerous prostates from HHV‐8 seropositive (n = 16) and seronegative (n = 2) men who died with AIDS were screened for expression of three viral proteins by immunohistochemistry. Levels of inflammation were determined by expression of CD68 and CD20. Cellular proliferation was determined by expression of Ki67. RESULTS Among the 16 HHV‐8 seropositive cases, 68.9% (11/16) (95% C.I. = 0.41–0.89) were positive for HHV‐8 protein expression, while the 2 seronegative patients showed no HHV‐8 protein expression. There was increased inflammation among HHV‐8 positive prostates. CONCLUSIONS These results demonstrate that HHV‐8 is present in normal prostates of HIV‐infected men and the expression of viral proteins is associated with increased localized inflammation. Prostate © 2006 Wiley‐Liss, Inc.
Editor: Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Idioma: Inglês

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Detection of human herpesvirus 8 (HHV-8) in normal prostates

Montgomery, J.D. ; Jacobson, L.P. ; Dhir, R. ; Jenkins, F.J.

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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