Idioma:

Evaluation of the anti-proliferative effect the extracts of Allamanda blanchetti and A. schottii on the growth of leukemic and endothelial cells

de F Navarro Schmidt, Dionezine ; Yunes, Rosendo A ; Schaab, Estela H ; Malheiros, Angela ; Cechinel Filho, Valdir ; Franchi, Jr, Gilberto C ; Nowill, Alexandre E ; Cardoso, Angelo A ; Yunes, José A

Journal of pharmacy & pharmaceutical sciences, 2006, Vol.9 (2), p.200-208 [Periódico revisado por pares]

Canada

Texto completo disponível

Citações Citado por

Enviar para

Título:
Evaluation of the anti-proliferative effect the extracts of Allamanda blanchetti and A. schottii on the growth of leukemic and endothelial cells
Autor: de F Navarro Schmidt, Dionezine ; Yunes, Rosendo A ; Schaab, Estela H ; Malheiros, Angela ; Cechinel Filho, Valdir ; Franchi, Jr, Gilberto C ; Nowill, Alexandre E ; Cardoso, Angelo A ; Yunes, José A
Assuntos: Antineoplastic Agents - pharmacology ; Apocynaceae - chemistry ; Cell Line, Tumor ; Endothelium, Vascular - drug effects ; Humans ; K562 Cells ; Plant Extracts - pharmacology ; Plant Roots - chemistry ; Plants, Medicinal - chemistry
É parte de: Journal of pharmacy & pharmaceutical sciences, 2006, Vol.9 (2), p.200-208
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: To investigate the anti-proliferative effect of A. blanchetti and A. schottii extracts. The anti-proliferative effect of A. blanchetti and A. schottii ethanolic extracts on K562 leukemic cells as well as on BMEC and HUVEC were evaluated. Phytochemical analysis to identify the possible active components was carried out. The root extract of A. schottii was the most active of them. At 80 microg/mL, the root extracts showed a cytostatic effect on K562, whereas at 400 microg/mL, there was a strong cytotoxic effect. Similar cytostatic and cytotoxic effects were seen in the endothelial cells, but at lower doses. The effect of A. schottii root extract on endothelial cells was seen at concentrations ten times lower (8 microg/mL) than the effect of the A. blanchetti root extract (80 microg/mL). Phytochemical investigation of different fractions and parts of the plant led to the isolation of several known compounds, some of which are described for the first time in the genus Allamanda, and with previous evidence of anticancer and antitumoral properties. Our results suggest that both plants studied exhibit cytostatic and cytotoxic activity, but the most active compounds are located in the roots.
Editor: Canada
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 8 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Evaluation of the anti-proliferative effect the extracts of Allamanda blanchetti and A. schottii on the growth of leukemic and endothelial cells

de F Navarro Schmidt, Dionezine ; Yunes, Rosendo A ; Schaab, Estela H ; Malheiros, Angela ; Cechinel Filho, Valdir ; Franchi, Jr, Gilberto C ; Nowill, Alexandre E ; Cardoso, Angelo A ; Yunes, José A

Canada

Buscando em bases de dados remotas. Favor aguardar.