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Regulation and functional relevance of milk fat globules and their components in the mammary gland

Aoki, N.(Mie Univ., Tsu (Japan))

Bioscience, biotechnology, and biochemistry, 2006-09, Vol.70 (9), p.2019-2027 [Periódico revisado por pares]

Tokyo: Japan Society for Bioscience Biotechnology and Agrochemistry

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Título:
Regulation and functional relevance of milk fat globules and their components in the mammary gland
Autor: Aoki, N.(Mie Univ., Tsu (Japan))
Assuntos: ACID PHOSPHATASE ; ANIMAL PHYSIOLOGY ; Animals ; Antigens, Surface - physiology ; Apoptosis - physiology ; Biological and medical sciences ; Butyrophilins ; Female ; FISIOLOGIA ANIMAL ; FOSFATASA ACIDA ; Fundamental and applied biological sciences. Psychology ; GLANDE MAMMAIRE ; GLANDULAS MAMARIAS ; Glycolipids - metabolism ; Glycolipids - physiology ; Glycolipids - secretion ; Glycoproteins - metabolism ; Glycoproteins - physiology ; Glycoproteins - secretion ; GRASA DE LA LECHE ; Lactation - physiology ; MAMIFEROS ; MAMMALS ; MAMMARY GLANDS ; Mammary Glands, Animal - enzymology ; Mammary Glands, Animal - physiology ; Mammary Glands, Animal - secretion ; MAMMIFERE ; MATIERE GRASSE DU LAIT ; Membrane Glycoproteins - physiology ; Mice ; Mice, Knockout ; MILK FAT ; Milk Proteins - metabolism ; Milk Proteins - secretion ; PHOSPHATASE ACIDE ; PHYSIOLOGIE ANIMALE ; PROLACTIN ; PROLACTINA ; PROLACTINE ; Protein Tyrosine Phosphatase, Non-Receptor Type 1 ; Protein Tyrosine Phosphatase, Non-Receptor Type 2 ; Protein Tyrosine Phosphatases - physiology ; TIROSINA ; TYROSINE
É parte de: Bioscience, biotechnology, and biochemistry, 2006-09, Vol.70 (9), p.2019-2027
Notas: 2007003732
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Descrição: Mammary gland and epithelial cells are unique to mammals and are under the control of lactogenic hormones such as prolactin. Recent findings indicated that major components of milk fat globule membrane (MFGM) are under the control of lactogenic hormones, and that the major components butyrophilin and xanthine oxidoreductase are indispensable for milk fat secretion. Further, prolactin signaling is negatively controlled by two highly related protein tyrosine phosphatases, PTP1B and TC-PTP. Milk fat globule EGF factor 8 (MFG-E8) is one of the major components of MFGM and is upregulated during lactation. MFG-E8 is further upregulated in the involuting mammary gland. MFG-E8 on exosome-like membrane vesicles in the milk recovered from post-weaning but not lactating mammary glands exhibits higher binding activity to phosphatidylserine and apoptotic mammary epithelial cells, and serves as a link between apoptotic mammary epithelial cells and phagocytes. Recent reports using MFG-E8 deficient mice support the view that MFG-E8 is indispensable for eliminating apoptotic mammary epithelial cells during involution.
Editor: Tokyo: Japan Society for Bioscience Biotechnology and Agrochemistry
Idioma: Inglês

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Regulation and functional relevance of milk fat globules and their components in the mammary gland

Aoki, N.(Mie Univ., Tsu (Japan))

Tokyo: Japan Society for Bioscience Biotechnology and Agrochemistry

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