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APOE alleles predict the rate of cognitive decline in Alzheimer disease : A nonlinear model

MARTINS, C. A. R ; OULHAJ, A ; DE JAGER, C. A ; WILLIAMS, J. H

Neurology, 2005-12, Vol.65 (12), p.1888-1893 [Periódico revisado por pares]

Hagerstown, MD: Lippincott Williams & Wilkins

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Título:
APOE alleles predict the rate of cognitive decline in Alzheimer disease : A nonlinear model
Autor: MARTINS, C. A. R ; OULHAJ, A ; DE JAGER, C. A ; WILLIAMS, J. H
Assuntos: Aged ; Aged, 80 and over ; Alzheimer Disease - genetics ; Alzheimer Disease - physiopathology ; Alzheimer Disease - psychology ; Apolipoprotein E2 ; Apolipoprotein E4 ; Apolipoproteins E - genetics ; Biological and medical sciences ; Cognition Disorders - genetics ; Cognition Disorders - physiopathology ; Cognition Disorders - psychology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Disease Progression ; Female ; Gene Dosage ; Gene Frequency ; Genetic Testing ; Genotype ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Heterozygote ; Homozygote ; Humans ; Male ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; Neuropsychological Tests ; Nonlinear Dynamics ; Polymorphism, Genetic - genetics ; Predictive Value of Tests ; Prognosis
É parte de: Neurology, 2005-12, Vol.65 (12), p.1888-1893
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: The APOE genotype predicts the age at onset of Alzheimer disease (AD) and neuropathologic progression. However, studies relating APOE alleles to the rate of cognitive decline have been inconclusive. This may stem from their use of linear statistical analyses. To model relations of APOE alleles to the rate of cognitive decline in AD, nonlinearly. Serial measures of cognitive ability were obtained using the cognitive scale of the Cambridge Examination for Mental Disorders of the Elderly in 218 patients with AD. The relations of these serial scores to APOE alleles were tested using nonlinear and linear mixed-effects models. In the non-linear model, possession of an APOE epsilon4 allele related to earlier and faster cognitive decline, but possession of an APOE epsilon2 related to slower decline. Patients homozygous for APOE epsilon4 showed faster cognitive decline than heterozygotes. The linear model was less sensitive and did not detect differences between APOE epsilon4 homo- and heterozygotes. APOE genotype strongly predicts the rate of cognitive decline in Alzheimer disease. The decline shows a dose-response relation with the APOE epsilon4 allele, but the APOE epsilon2 allele is protective. The nonlinear model yielded larger estimates of the maximal rate of decline than the linear.
Editor: Hagerstown, MD: Lippincott Williams & Wilkins
Idioma: Inglês

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APOE alleles predict the rate of cognitive decline in Alzheimer disease : A nonlinear model

MARTINS, C. A. R ; OULHAJ, A ; DE JAGER, C. A ; WILLIAMS, J. H

Hagerstown, MD: Lippincott Williams & Wilkins

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