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Vaginal microbicides : the importance of effective distribution, retention and coating of the mucosa

DAS NEVES, José ; SANTOS, Barbara ; CUNHA, Teresa ; TEIXEIRA, Branca ; ROCHA, Patrocinia ; DIAS, Gustavo

AIDS (London), 2008-04, Vol.22 (7), p.908-909 [Periódico revisado por pares]

Hagerstown, MD: Lippincott Williams & Wilkins

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Título:
Vaginal microbicides : the importance of effective distribution, retention and coating of the mucosa
Autor: DAS NEVES, José ; SANTOS, Barbara ; CUNHA, Teresa ; TEIXEIRA, Branca ; ROCHA, Patrocinia ; DIAS, Gustavo
Assuntos: AIDS/HIV ; Anti-Infective Agents - administration & dosage ; Biological and medical sciences ; Drug Delivery Systems ; Female ; HIV Infections - prevention & control ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Mucous Membrane ; Vagina ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids
É parte de: AIDS (London), 2008-04, Vol.22 (7), p.908-909
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Descrição: Since the early days of microbicide development, this preventive strategy has been considered promising in the battle against sexually transmitted HIV infection. Now, more than a decade has passed and all major clinical trial results show that these vaginal formulations not only failed to achieve their objectives, but also, in some cases, actually enhanced HIV transmission. Confronted with these unexpected outcomes, the scientific community is now trying to find explanations and rethink strategies to circumvent these poor results. Recently, van de Wijgert and Shattock addressed an interesting review of likely explanations for microbicide failure. However, we believe that important issues related to the performance of microbicide-containing drug delivery systems used in the past and currently ongoing clinical trials were not discussed, which we would like to address next.
Editor: Hagerstown, MD: Lippincott Williams & Wilkins
Idioma: Inglês

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Vaginal microbicides : the importance of effective distribution, retention and coating of the mucosa

DAS NEVES, José ; SANTOS, Barbara ; CUNHA, Teresa ; TEIXEIRA, Branca ; ROCHA, Patrocinia ; DIAS, Gustavo

Hagerstown, MD: Lippincott Williams & Wilkins

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