skip to main content
Guest
e-Shelf
My Account
Sign out
Sign in
This feature requires javascript
Tags
e-Journals
e-Books
Databases
USP Libraries
Help
Help
Language:
English
Spanish
Portuguese (Brazil)
This feature required javascript
This feature requires javascript
Primo Search
General Search
General Search
Physical Collection
Physical Collections
USP Intelectual Production
USP Production
Search For:
Clear Search Box
Search in:
General Search
Or hit Enter to replace search target
Or select another collection:
Search in:
General Search
Advanced Search
Browse Search
This feature requires javascript
This feature requires javascript
Limb-girdle muscular dystrophies
Guglieri, Michela ; Straub, Volker ; Bushby, Kate ; Lochmüller, Hanns DiMauro, S
Current opinion in neurology, 2008-10, Vol.21 (5), p.576-584
[Peer Reviewed Journal]
England
Full text available
Citations
Cited by
View Online
Details
Reviews & Tags
More
Times Cited
This feature requires javascript
Actions
Add to e-Shelf
Remove from e-Shelf
E-mail
Print
Permalink
Citation
EasyBib
EndNote
RefWorks
Delicious
Export RIS
Export BibTeX
This feature requires javascript
Title:
Limb-girdle muscular dystrophies
Author:
Guglieri, Michela
;
Straub, Volker
;
Bushby, Kate
;
Lochmüller, Hanns
DiMauro, S
Subjects:
Diagnosis, Differential
;
Humans
;
Muscular Dystrophies, Limb-Girdle - classification
;
Muscular Dystrophies, Limb-Girdle - diagnosis
;
Muscular Dystrophies, Limb-Girdle - genetics
;
Muscular Dystrophies, Limb-Girdle - therapy
;
Prognosis
Is Part Of:
Current opinion in neurology, 2008-10, Vol.21 (5), p.576-584
Notes:
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Feature-3
ObjectType-Review-1
Description:
The aim of this review is to provide an up-to-date analysis of current knowledge about limb-girdle muscular dystrophies (LGMDs). Over the last few years, new and interesting studies have been published on LGMD. New LGMD genes have been discovered and the clinical and genetic heterogeneity in this group of muscular dystrophies has been further enlarged by the description of new forms of LGMD. Several studies have demonstrated involvement of genes causing posttranslational modifications of alpha-dystroglycan in the pathogenesis of autosomal recessive LGMD. This has highlighted an important overlap in pathogenesis between LGMD and congenital muscular dystrophies, prompting further research. Moreover, new pathogenic mechanisms and pathways are emerging for LGMD, in particular calpainopathies, dysferlinopathies and titinopathies. Such new findings may suggest novel therapeutic approaches and future clinical trials. The increased understanding of the genes and pathogenic mechanism of the LGMDs will improve diagnostic processes and prognostic accuracy, and promote therapeutic strategies. European and global LGMD patient registries will increase current knowledge on natural history and facilitate translational research.
Publisher:
England
Language:
English
Links
View this record in MEDLINE/PubMed
This feature requires javascript
This feature requires javascript
Back to results list
Previous
Result
3
Next
This feature requires javascript
This feature requires javascript
Searching Remote Databases, Please Wait
Searching for
in
scope:(USP_VIDEOS),scope:("PRIMO"),scope:(USP_FISICO),scope:(USP_EREVISTAS),scope:(USP),scope:(USP_EBOOKS),scope:(USP_PRODUCAO),primo_central_multiple_fe
Show me what you have so far
This feature requires javascript
This feature requires javascript