Idioma:

Assessment of PTEN tumor suppressor activity in nonmammalian models: the year of the yeast

CID, V. J ; RODRIGUEZ-ESCUDERO, I ; ANDRES-PONS, A ; ROMH-MATEO, C ; GIL, A ; DEN HERTOG, J ; MOLINA, M ; PULIDO, R

Oncogene, 2008-09, Vol.27 (41), p.5431-5442 [Periódico revisado por pares]

Basingstoke: Nature Publishing

Texto completo disponível

Citações Citado por

Enviar para

Título:
Assessment of PTEN tumor suppressor activity in nonmammalian models: the year of the yeast
Autor: CID, V. J ; RODRIGUEZ-ESCUDERO, I ; ANDRES-PONS, A ; ROMH-MATEO, C ; GIL, A ; DEN HERTOG, J ; MOLINA, M ; PULIDO, R
Assuntos: 1-Phosphatidylinositol 3-kinase ; Amino Acid Sequence ; Amoeba ; Animal models ; Animals ; Biological and medical sciences ; Cell physiology ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Cellular signal transduction ; Eukaryotic Cells - metabolism ; Eukaryotic Cells - physiology ; Fundamental and applied biological sciences. Psychology ; Genes, Tumor Suppressor - physiology ; Genetic aspects ; Genetics ; Health aspects ; Humans ; Models, Biological ; Molecular and cellular biology ; Molecular Sequence Data ; Oncology ; Phenotypes ; Phosphatidylinositol 3,4,5-triphosphate ; Phosphatidylinositol 3-Kinases - physiology ; Phosphatidylinositol 4,5-diphosphate ; Phylogeny ; Physiological aspects ; Proteins ; PTEN Phosphohydrolase - genetics ; PTEN Phosphohydrolase - metabolism ; PTEN Phosphohydrolase - physiology ; PTEN protein ; Saccharomyces cerevisiae ; Sequence Homology ; Signal Transduction - genetics ; Signal Transduction - physiology ; Tumor suppressor genes ; Tumors ; Yeast ; Yeast fungi ; Yeasts - genetics ; Yeasts - physiology
É parte de: Oncogene, 2008-09, Vol.27 (41), p.5431-5442
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Article-2
ObjectType-Feature-3
ObjectType-Review-1
Descrição: Model organisms have emerged as suitable and reliable biological tools to study the properties of proteins whose function is altered in human disease. In the case of the PI3K and PTEN human cancer-related proteins, several vertebrate and invertebrate models, including mouse, fly, worm and amoeba, have been exploited to obtain relevant functional information that has been conserved from these organisms to humans along evolution. The yeast Saccharomyces cerevisiae is an eukaryotic unicellular organism that lacks a canonical mammalian-like PI3K/PTEN pathway and PIP3 as a physiological second messenger, PIP2 being essential for its life. The mammalian PI3K/PTEN pathway can be reconstituted in S. cerevisiae, generating growth alteration phenotypes that can be easily monitored to perform in vivo functional analysis of the molecular constituents of this pathway. Here, we review the current nonmammalian model systems to study PTEN function, summarize our knowledge of PTEN orthologs in yeast species and propose the yeast S. cerevisiae as a sensitive biological sensor of PI3K oncogenicity and PTEN tumor suppressor activity.
Editor: Basingstoke: Nature Publishing
Idioma: Inglês

Links

Voltar para lista de resultados

Anterior Resultado 5 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Assessment of PTEN tumor suppressor activity in nonmammalian models: the year of the yeast

CID, V. J ; RODRIGUEZ-ESCUDERO, I ; ANDRES-PONS, A ; ROMH-MATEO, C ; GIL, A ; DEN HERTOG, J ; MOLINA, M ; PULIDO, R

Basingstoke: Nature Publishing

Buscando em bases de dados remotas. Favor aguardar.