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Extracorporeal photopheresis for the treatment of steroid refractory acute GVHD

PERFETTI, P ; CARLIER, P ; DOMINIETTO, A ; DI GRAZIA, C ; BREGANTE, S ; ZIA, S ; FERRARI, G. M ; STURA, P ; POGLIANI, E ; BACIGALUPO, A ; STRADA, P ; GUALANDI, F ; OCCHINI, D ; VAN LINT, M. T ; IBATICI, A ; LAMPARELLI, T ; BRUNO, B ; RAIOLA, A. M

Bone marrow transplantation (Basingstoke), 2008-11, Vol.42 (9), p.609-617 [Periódico revisado por pares]

Basingstoke: Nature Publishing Group

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Extracorporeal photopheresis for the treatment of steroid refractory acute GVHD
Autor: PERFETTI, P ; CARLIER, P ; DOMINIETTO, A ; DI GRAZIA, C ; BREGANTE, S ; ZIA, S ; FERRARI, G. M ; STURA, P ; POGLIANI, E ; BACIGALUPO, A ; STRADA, P ; GUALANDI, F ; OCCHINI, D ; VAN LINT, M. T ; IBATICI, A ; LAMPARELLI, T ; BRUNO, B ; RAIOLA, A. M
Assuntos: Acute Disease ; Adolescent ; Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Apheresis ; Biological and medical sciences ; Bone marrow ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Cancer ; Care and treatment ; Chronic Disease ; Drug Resistance ; Female ; Graft versus host reaction ; Graft vs Host Disease - drug therapy ; Graft vs Host Disease - immunology ; Health aspects ; Hematopoietic Stem Cell Transplantation - adverse effects ; Humans ; Immunosuppression - methods ; Leukemia ; Male ; Medical sciences ; Methylprednisolone ; Middle Aged ; Patients ; Photochemotherapy ; Photodynamic therapy ; Photopheresis - adverse effects ; Photopheresis - methods ; Retrospective Studies ; Stem cell transplantation ; Steroids ; Steroids (Drugs) ; Steroids - therapeutic use ; Survival Rate ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Transplantation Conditioning ; Treatment Outcome ; Young Adult
É parte de: Bone marrow transplantation (Basingstoke), 2008-11, Vol.42 (9), p.609-617
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SourceType-Scholarly Journals-1
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Descrição: Extracorporeal photopheresis (ECP) was given to 23 patients with steroid-refractory acute GVHD (aGVHD, grade II (n=10), III (n=7) or IV (n=6)). The median duration of ECP was 7 months (1-33) and the median number of ECP cycles in each patient was 10. Twelve patients (52%) had complete responses. Eleven patients (48%) survived and 12 died, 10 of GVHD with or without infections and two of leukaemia relapse. The average grade of GVHD was reduced from 2.8 (on the first day of ECP) to 1.4 (on day +90 from ECP) (P=0.08), and the average dose of i.v. methylprednisolone from 2.17 to 0.2 mg/kg/d (P=0.004). Complete responses were obtained in 70, 42 and 0% of patients, respectively, with grades II, III and IV aGVHD; complete responses in the skin, liver and gut were 66, 27 and 40%. Patients treated within 35 days from onset of aGVHD had higher responses (83 vs 47%; P=0.1). A trend for improved survival was seen in grade III-IV aGVHD treated with ECP as compared to matched controls (38 vs 16%; P 0.08). ECP is a treatment option for patients with steroid refractory aGVHD and should be considered early in the course of the disease.
Editor: Basingstoke: Nature Publishing Group
Idioma: Inglês

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Extracorporeal photopheresis for the treatment of steroid refractory acute GVHD

PERFETTI, P ; CARLIER, P ; DOMINIETTO, A ; DI GRAZIA, C ; BREGANTE, S ; ZIA, S ; FERRARI, G. M ; STURA, P ; POGLIANI, E ; BACIGALUPO, A ; STRADA, P ; GUALANDI, F ; OCCHINI, D ; VAN LINT, M. T ; IBATICI, A ; LAMPARELLI, T ; BRUNO, B ; RAIOLA, A. M

Basingstoke: Nature Publishing Group

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