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Infrequent Germ-line Mutation of the E-cadherin Gene in Japanese Familial Gastric Cancer Kindreds

IIDA, S ; AKIYAMA, Y ; ICHIKAWA, W ; YAMASHITA, T ; NOMIZU, T ; NIHEI, Z ; SUGIHARA, K ; YUASA, Y

Clinical cancer research, 1999-06, Vol.5 (6), p.1445-1447 [Periódico revisado por pares]

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Título:
Infrequent Germ-line Mutation of the E-cadherin Gene in Japanese Familial Gastric Cancer Kindreds
Autor: IIDA, S ; AKIYAMA, Y ; ICHIKAWA, W ; YAMASHITA, T ; NOMIZU, T ; NIHEI, Z ; SUGIHARA, K ; YUASA, Y
Assuntos: Adolescent ; Adult ; Aged ; Biological and medical sciences ; Cadherins - genetics ; DNA Mutational Analysis ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Genetic Predisposition to Disease ; Germ-Line Mutation ; Humans ; Japan ; Male ; Medical sciences ; Middle Aged ; Polymerase Chain Reaction ; Polymorphism, Single-Stranded Conformational ; Stomach Neoplasms - genetics ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors
É parte de: Clinical cancer research, 1999-06, Vol.5 (6), p.1445-1447
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Germ-line mutation of the E-cadherin gene was reported in familial gastric cancer (FGC) kindreds from New Zealand. Therefore, we analyzed all of the exons of E-cadherin by PCR-single-strand conformational polymorphism analysis in 16 patients from 14 Japanese FGC kindreds. However, no germ-line mutation was detected, suggesting that a predisposition to FGCs by E-cadherin gene mutation is infrequent in Japanese cases.
Editor: Philadelphia, PA: American Association for Cancer Research
Idioma: Inglês

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