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Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle

Marzetti, Emanuele ; Lawler, John M. ; Hiona, Asimina ; Manini, Todd ; Seo, Arnold Y. ; Leeuwenburgh, Christiaan

Free radical biology & medicine, 2008-01, Vol.44 (2), p.160-168 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle
Autor: Marzetti, Emanuele ; Lawler, John M. ; Hiona, Asimina ; Manini, Todd ; Seo, Arnold Y. ; Leeuwenburgh, Christiaan
Assuntos: Adaptation, Physiological - physiology ; Aging ; Aging - physiology ; Animals ; Apoptosis ; Apoptosis - physiology ; Caloric Restriction ; Calorie restriction ; Caspases ; Cell Physiological Phenomena ; Cell signaling ; Exercise - physiology ; Exercise Test ; Exercise training ; Free radicals ; Humans ; Mitochondria ; Models, Animal ; Models, Biological ; Muscle ; Muscle, Skeletal - physiology ; Muscular Atrophy - etiology ; Muscular Atrophy - prevention & control ; Physical Conditioning, Animal - physiology ; Physical Fitness - physiology ; Proteases ; Rodentia ; Sarcopenia ; Signal Transduction - physiology
É parte de: Free radical biology & medicine, 2008-01, Vol.44 (2), p.160-168
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
Descrição: Aging is inevitably associated with a progressive loss of muscle mass and strength, a condition also known as sarcopenia of aging. Although the precise mechanisms underlying this syndrome have not been completely elucidated, recent studies point toward several key cellular mechanisms that could contribute to age-associated muscle loss. Among these, mitochondrial dysfunction and deregulation of apoptotic signaling have emerged as critical players in the onset and progression of sarcopenia. Interestingly, calorie restriction, a well-known antiaging intervention, and, more recently, exercise training have been shown to beneficially affect both mitochondrial function and apoptotic signaling in skeletal muscle from young and old animals. Preliminary observations also indicate that even a small (8%) reduction in food intake may still provide protective effects against sarcopenia and cellular remodeling in aging skeletal muscle, with the advantage of being more applicable to human subjects than the traditional 30–40% restriction regimen. The most recent evidence on the relevance of skeletal muscle apoptosis to sarcopenia, as well as its modulation by calorie restriction and exercise, is reviewed.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle

Marzetti, Emanuele ; Lawler, John M. ; Hiona, Asimina ; Manini, Todd ; Seo, Arnold Y. ; Leeuwenburgh, Christiaan

United States: Elsevier Inc

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