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The anatomical bases of semantic retrieval deficits in early Alzheimer's disease

Venneri, Annalena ; McGeown, William J. ; Hietanen, Heidi M. ; Guerrini, Chiara ; Ellis, Andrew W. ; Shanks, Michael F.

Neuropsychologia, 2008-01, Vol.46 (2), p.497-510 [Periódico revisado por pares]

Oxford: Elsevier Ltd

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Título:
The anatomical bases of semantic retrieval deficits in early Alzheimer's disease
Autor: Venneri, Annalena ; McGeown, William J. ; Hietanen, Heidi M. ; Guerrini, Chiara ; Ellis, Andrew W. ; Shanks, Michael F.
Assuntos: Adult and adolescent clinical studies ; Aged ; Aged, 80 and over ; Alzheimer Disease - pathology ; Alzheimer's disease ; Biological and medical sciences ; Brain Mapping ; Case-Control Studies ; Category fluency ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Functional Laterality ; Humans ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging ; Male ; Matched-Pair Analysis ; Medical sciences ; Mental Recall - physiology ; Middle Aged ; Neurology ; Neuropsychological Tests ; Organic mental disorders. Neuropsychology ; Parahippocampal Gyrus - pathology ; Parahippocampal Gyrus - physiology ; Perirhinal ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Reference Values ; Semantic retrieval ; Semantics ; Severity of Illness Index ; Temporal Lobe - pathology ; Temporal Lobe - physiology ; Voxel-based morphometry
É parte de: Neuropsychologia, 2008-01, Vol.46 (2), p.497-510
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Semantic abilities deteriorate early in patients with Alzheimer's disease (AD) and their residual language is characterised by strong lexical effects such as the age of acquisition of words and their typicality. The anatomical bases of this early semantic degradation have not been fully explored. To clarify which neural structures, when atrophic, alter lexical–semantic function in patients with very mild AD, this study correlated the lexical attributes of words produced in a semantic fluency task with grey matter density values from 3D MRI scans of mild AD patients. The voxel-based analyses showed a significant correlation between the lexical attributes characterising residual linguistic production in early AD patients and the integrity of regions of the medial temporal lobes, especially in areas of the perirhinal and parahippocampal cortex. This correlation was present in both hemispheres. There were no correlations within these structures with scores on neuropsychological tests not involving semantic or episodic memory. The results have implications for the role of medial temporal structures in episodic and semantic retrieval and argue against a unitary function of these structures in respect of episodic and semantic memory processes. This evidence suggests that specialised regions within the hippocampal complex engage in processes of encoding and retrieval for both semantic and episodic memories.
Editor: Oxford: Elsevier Ltd
Idioma: Inglês

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The anatomical bases of semantic retrieval deficits in early Alzheimer's disease

Venneri, Annalena ; McGeown, William J. ; Hietanen, Heidi M. ; Guerrini, Chiara ; Ellis, Andrew W. ; Shanks, Michael F.

Oxford: Elsevier Ltd

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