Idioma:

Short-term, high-fat diets lower circulating leptin concentrations in rats

AINSLIE, D. A ; PROIETTO, J ; FAM, B. C ; THORBURN, A. W

The American journal of clinical nutrition, 2000-02, Vol.71 (2), p.438-442 [Periódico revisado por pares]

Bethesda, MD: American Society for Clinical Nutrition

Texto completo disponível

Citações Citado por

Enviar para

Título:
Short-term, high-fat diets lower circulating leptin concentrations in rats
Autor: AINSLIE, D. A ; PROIETTO, J ; FAM, B. C ; THORBURN, A. W
Assuntos: Adipose Tissue - drug effects ; Adipose Tissue - metabolism ; Animals ; Biological and medical sciences ; Body Weight ; Diet ; Dietary Carbohydrates - administration & dosage ; Dietary Fats - administration & dosage ; Dietary Fats - pharmacology ; Dietary Proteins - administration & dosage ; Energy Intake ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Insulin - blood ; Leptin - blood ; Nutrition ; Obesity - blood ; Oils & fats ; Rats ; Rats, Wistar ; Rodents ; Time Factors ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Weight
É parte de: The American journal of clinical nutrition, 2000-02, Vol.71 (2), p.438-442
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Leptin is produced in proportion to body fat mass and can act on the brain to induce satiety and regulate adipose tissue mass; factors other than adipose tissue mass may influence circulating leptin concentrations. We explored the possibility that short-term, moderately high-fat diets induce weight gain by producing inappropriately low circulating leptin concentrations. Female Hooded Wistar rats were fed either a moderately high-fat diet or control diet. Body weight, energy intake, body composition, and fasting plasma leptin were compared after 4 and 14 wk of dietary treatment. After 4 wk, abdominal fat mass was 38% greater in rats fed the high-fat diet than in those fed the control diet (P < 0.01). However, plasma leptin concentrations were 24% lower in animals fed the high-fat diet (P < 0.05), resulting in significantly lower plasma leptin concentrations per unit abdominal fat mass than in control animals (P < 0.005). From 4 to 14 wk, animals fed the high-fat diet gained twice as much weight and consumed 32 kJ/d more than controls (both P < 0.05). At 14 wk, plasma leptin concentrations per unit abdominal fat mass were 27% lower in rats fed the high-fat diet (P = 0.058) and there was a significant negative association between leptin concentrations per unit abdominal fat mass and body weight (r = 0.44, P < 0.05). In the short term, a moderately high-fat diet is associated with lower than expected circulating leptin concentrations, which correlate with a higher body weight. A high-fat diet may therefore contribute to weight gain by reducing leptin secretion in adipose tissue.
Editor: Bethesda, MD: American Society for Clinical Nutrition
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Short-term, high-fat diets lower circulating leptin concentrations in rats

AINSLIE, D. A ; PROIETTO, J ; FAM, B. C ; THORBURN, A. W

Bethesda, MD: American Society for Clinical Nutrition

Buscando em bases de dados remotas. Favor aguardar.