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10-Gy Single-Fraction Pelvic Irradiation for Palliation and Life Prolongation in Patients with Cancer of the Cervix and Corpus Uteri

Onsrud, Mathias ; Hagen, Bjørn ; Strickert, Trond

Gynecologic oncology, 2001-07, Vol.82 (1), p.167-171 [Periódico revisado por pares]

San Diego, CA: Elsevier Inc

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Título:
10-Gy Single-Fraction Pelvic Irradiation for Palliation and Life Prolongation in Patients with Cancer of the Cervix and Corpus Uteri
Autor: Onsrud, Mathias ; Hagen, Bjørn ; Strickert, Trond
Assuntos: 10-Gy single fraction ; Adenocarcinoma - complications ; Adenocarcinoma - mortality ; Adenocarcinoma - radiotherapy ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma, Squamous Cell - complications ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - radiotherapy ; Female ; Genital system. Mammary gland ; gynecologic malignancy ; Humans ; hypofractionation ; Life Support Care - methods ; Medical sciences ; Neoplasm Staging ; palliation ; Palliative Care - methods ; Pelvis - radiation effects ; radiotherapy ; Radiotherapy Dosage ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Retrospective Studies ; Survival Rate ; Treatment Outcome ; Uterine Cervical Neoplasms - complications ; Uterine Cervical Neoplasms - mortality ; Uterine Cervical Neoplasms - radiotherapy ; Uterine Neoplasms - complications ; Uterine Neoplasms - mortality ; Uterine Neoplasms - radiotherapy
É parte de: Gynecologic oncology, 2001-07, Vol.82 (1), p.167-171
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Descrição: Objective. The goal of this study was to evaluate the effects of single fractions of 10 Gy pelvic irradiation for palliation and life prolongation in patients with cancer of the uterine cervix or corpus. Methods. A retrospective analysis was performed on 37 cervical cancer and 27 corpus cancer patients treated in the period 1988–1998. All patients had a life expectancy of less than 1 year. Due to stage of disease, age (median 82 years), or comorbidity they were considered unapt for surgery or conventional radiotherapy. Eleven patients with recurrence within irradiated field or early progression received one, 51 patients received two, and 2 patients received three fractions with a 4-week interval. Results. Vaginal bleeding stopped in 90% and malodorous discharge in 39% of the patients. Among 46 patients with advanced disease treated for palliation, 10 (22%) showed complete tumor responses. Median time to progression was 6 months, and median survival, 9 months. Eighteen patients with early-stage disease and serious comorbidity were treated with life prolongation and symptom prevention as intention, and showed seven complete responses. Median survival was 13 months, and half the deaths were caused by intercurrent disease. Median hospital stay was 5 days and rehabilitation was easy. Fifty-six percent of the patients experienced no acute side effects and 33% had minor gastrointestinal problems. Three patients (6%) had serious late bowel complications, one with a fatal outcome, the symptoms appearing 9–10 months posttreatment. Conclusion. The 10-Gy single-fraction pelvic radiation regimen is an effective means of symptom palliation and is well tolerated. Tumor responses are obtained. The risk of late bowel complications is a concern for patients with a life expectancy greater than 9 months.
Editor: San Diego, CA: Elsevier Inc
Idioma: Inglês

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10-Gy Single-Fraction Pelvic Irradiation for Palliation and Life Prolongation in Patients with Cancer of the Cervix and Corpus Uteri

Onsrud, Mathias ; Hagen, Bjørn ; Strickert, Trond

San Diego, CA: Elsevier Inc

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