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A method for reducing the time required to match protein sequences with tandem mass spectra

Craig, Robertson ; Beavis, Ronald C.

Rapid communications in mass spectrometry, 2003-01, Vol.17 (20), p.2310-2316 [Periódico revisado por pares]

Chichester, UK: John Wiley & Sons, Ltd

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  • Título:
    A method for reducing the time required to match protein sequences with tandem mass spectra
  • Autor: Craig, Robertson ; Beavis, Ronald C.
  • Assuntos: Algorithms ; Amino Acid Sequence ; Databases, Protein ; Information Storage and Retrieval - methods ; Mass Spectrometry - methods ; Proteins - chemistry ; Software ; Time Factors
  • É parte de: Rapid communications in mass spectrometry, 2003-01, Vol.17 (20), p.2310-2316
  • Notas: Canadian Institutes for Health Research
    The Yen Foundation
    istex:62072E14AF9B5BE3410C19787771DDA2AB158A4C
    ark:/67375/WNG-S89B7X8Z-8
    Proteometrics Canada Ltd.
    ArticleID:RCM1198
    ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: An algorithm for reducing the time necessary to match a large set of peptide tandem mass spectra with a list of protein sequences is described. This algorithm breaks the process into multiple steps. A rapid survey step identifies all protein sequences that are reasonable candidates for a match with a set of tandem mass spectra. These candidates are then used as models, which are refined by detailed analysis of the set of tandem mass spectra for evidence of incomplete enzymatic hydrolysis, non‐specific hydrolysis and chemical modifications of amino acid residues resulting from either post‐translational modifications or sample handling. Compared with current one‐step methods for matching proteins to mass spectra, this multiple‐step method can decrease the time required for the calculation by several orders of magnitude. Copyright © 2003 John Wiley & Sons, Ltd.
  • Editor: Chichester, UK: John Wiley & Sons, Ltd
  • Idioma: Inglês
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