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Influence of interhemispheric interactions on motor function in chronic stroke

Murase, Nagako ; Duque, Julie ; Mazzocchio, Riccardo ; Cohen, Leonardo G.

Annals of neurology, 2004-03, Vol.55 (3), p.400-409 [Periódico revisado por pares]

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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Título:
Influence of interhemispheric interactions on motor function in chronic stroke
Autor: Murase, Nagako ; Duque, Julie ; Mazzocchio, Riccardo ; Cohen, Leonardo G.
Assuntos: Adult ; Aged ; Biological and medical sciences ; Case-Control Studies ; Chronic Disease ; Conditioning (Psychology) ; Electric Stimulation - methods ; Electromyography - methods ; Evoked Potentials, Motor - physiology ; Evoked Potentials, Motor - radiation effects ; Female ; Fingers - physiology ; Functional Laterality ; Humans ; Male ; Medical sciences ; Middle Aged ; Motor Activity - physiology ; Motor Cortex - physiology ; Movement ; Neurology ; Paresis - etiology ; Paresis - physiopathology ; Psychomotor Performance ; Reaction Time ; Recovery of Function - physiology ; Stroke - physiopathology ; Time Factors
É parte de: Annals of neurology, 2004-03, Vol.55 (3), p.400-409
Notas: ark:/67375/WNG-WTZ3FRHS-G
ArticleID:ANA10848
This article is a US Government work and, as such, is in the public domain in the United States of America.
istex:DD864B7D430E98D78F62225C31F33A5917BE517C
ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: In patients with chronic stroke, the primary motor cortex of the intact hemisphere (M1intact hemisphere) may influence functional recovery, possibly through transcallosal effects exerted over M1 in the lesioned hemisphere (M1lesioned hemisphere). Here, we studied interhemispheric inhibition (IHI) between M1intact hemisphere and M1lesioned hemisphere in the process of generation of a voluntary movement by the paretic hand in patients with chronic subcortical stroke and in healthy volunteers. IHI was evaluated in both hands preceding the onset of unilateral voluntary index finger movements (paretic hand in patients, right hand in controls) in a simple reaction time paradigm. IHI at rest and shortly after the Go signal were comparable in patients and controls. Closer to movement onset, IHI targeting the moving index finger turned into facilitation in controls but remained deep in patients, a finding that correlated with poor motor performance. These results document an abnormally high interhemispheric inhibitory drive from M1intact hemisphere to M1lesioned hemisphere in the process of generation of a voluntary movement by the paretic hand. It is conceivable that this abnormality could adversely influence motor recovery in some patients with subcortical stroke, an interpretation consistent with models of interhemispheric competition in motor and sensory systems.
Editor: Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Idioma: Inglês

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Influence of interhemispheric interactions on motor function in chronic stroke

Murase, Nagako ; Duque, Julie ; Mazzocchio, Riccardo ; Cohen, Leonardo G.

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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