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Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

Beere, Helen M ; Wolf, Beni B ; Cain, Kelvin ; Mosser, Dick D ; Mahboubi, Artin ; Kuwana, Tomomi ; Tailor, Pankaj ; Morimoto, Richard I ; Cohen, Gerald M ; Green, Douglas R

Nature cell biology, 2000-08, Vol.2 (8), p.469-475 [Periódico revisado por pares]

England: Nature Publishing Group

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Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome
Autor: Beere, Helen M ; Wolf, Beni B ; Cain, Kelvin ; Mosser, Dick D ; Mahboubi, Artin ; Kuwana, Tomomi ; Tailor, Pankaj ; Morimoto, Richard I ; Cohen, Gerald M ; Green, Douglas R
Assuntos: Apoptosis ; Apoptotic Protease-Activating Factor 1 ; Binding Sites ; Biochemistry ; Biology ; Caspase 9 ; Caspases - chemistry ; Caspases - metabolism ; Cell death ; Cell Line ; Cell-Free System ; Chromatography, Gel ; Cytochrome ; Cytochrome c Group - metabolism ; Deoxyadenine Nucleotides - antagonists & inhibitors ; Deoxyadenine Nucleotides - pharmacology ; Enzyme Activation - drug effects ; Enzyme Precursors - chemistry ; Enzyme Precursors - metabolism ; Heat shock proteins ; Hot Temperature ; HSP70 Heat-Shock Proteins - metabolism ; Humans ; Jurkat Cells ; Ligands ; Macromolecular Substances ; Physiological aspects ; Physiology ; Protein Binding ; Protein Processing, Post-Translational ; Protein Structure, Tertiary ; Proteins - chemistry ; Proteins - metabolism ; Recombinant Proteins - metabolism ; Substrate Specificity ; Transfection
É parte de: Nature cell biology, 2000-08, Vol.2 (8), p.469-475
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: The cellular-stress response can mediate cellular protection through expression of heat-shock protein (Hsp) 70, which can interfere with the process of apoptotic cell death. Stress-induced apoptosis proceeds through a defined biochemical process that involves cytochrome c, Apaf-1 and caspase proteases. Here we show, using a cell-free system, that Hsp70 prevents cytochrome c/dATP-mediated caspase activation, but allows the formation of Apaf-1 oligomers. Hsp70 binds to Apaf-1 but not to procaspase-9, and prevents recruitment of caspases to the apoptosome complex. Hsp70 therefore suppresses apoptosis by directly associating with Apaf-1 and blocking the assembly of a functional apoptosome.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

Beere, Helen M ; Wolf, Beni B ; Cain, Kelvin ; Mosser, Dick D ; Mahboubi, Artin ; Kuwana, Tomomi ; Tailor, Pankaj ; Morimoto, Richard I ; Cohen, Gerald M ; Green, Douglas R

England: Nature Publishing Group

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