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Incidence and remission of asthma: A retrospective study on the natural history of asthma in Italy

de Marco, Roberto ; Locatelli, Francesca ; Cerveri, Isa ; Bugiani, Massimiliano ; Marinoni, Alessandra ; Giammanco, Giuseppe

Journal of allergy and clinical immunology, 2002-08, Vol.110 (2), p.228-235 [Revista revisada por pares]

New York, NY: Mosby, Inc

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  • Título:
    Incidence and remission of asthma: A retrospective study on the natural history of asthma in Italy
  • Autor: de Marco, Roberto ; Locatelli, Francesca ; Cerveri, Isa ; Bugiani, Massimiliano ; Marinoni, Alessandra ; Giammanco, Giuseppe
  • Materias: Adolescent ; Adult ; Allergic diseases ; Asthma ; Asthma - epidemiology ; Bias ; Biological and medical sciences ; Child ; Child, Preschool ; Cross-Sectional Studies ; Estimates ; Female ; Humans ; Immunopathology ; Incidence ; Infant ; Infant, Newborn ; Italy - epidemiology ; Male ; Medical sciences ; National Health Programs ; Recall ; Remission, Spontaneous ; Respiratory and ent allergic diseases ; Response rates ; Retrospective Studies ; Studies
  • Es parte de: Journal of allergy and clinical immunology, 2002-08, Vol.110 (2), p.228-235
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descripción: Background: The knowledge of the natural history of asthma from birth to adulthood could provide important clues for its cause and for the understanding of epidemiologic findings. Objective: This study is aimed at assessing the incidence and remission of asthma from birth to the age of 44 years by using data from 18,873 subjects involved in a large, nationally representative, cross-sectional study carried out in Italy from 1998 through 2000. Methods: The onset of asthma was defined as the age at the first attack, and remission was considered present when a subject was neither under treatment nor had experienced an asthma attack in the last 24 months. Person-years and survival techniques were used for the analysis. Results: The average annual incidence rate for the 1953 to 2000 period was 2.56/1000 persons per year. Incidence peaked in boys less than 10 years of age (4.38/1000 persons per year) and in women 30 years of age or older (3.1/1000 persons per year) and showed a generational increase (incident rate ratio = 2.63 and 95% CI = 2.20-3.12 for 1974-1979 vs 1953-1958 birth cohort). The overall remission rate was 45.8% (41.6% in women and 49.5% in men, P < .001). Asthmatic patients in remission had an earlier age at onset (7.8 vs 15.9 years, P < .001) and a shorter duration of the disease (5.6 vs 16.1 years, P < .001) than patients with current asthma. The probability of remission was strongly ( P < .001) and inversely related to the age at onset (62.8% and 15.0% in the <10- and ≥20-years age-at-onset groups, respectively). Conclusion: With respect to its natural history, asthma presents 2 different forms: early-onset asthma, which occurs early in childhood, affects mainly boys, and has a good prognosis, and late-onset asthma, which generally occurs during or after puberty, mainly affects women, and has a poor prognosis. The minority of patients with early-onset asthma who do not remit represents more than 35% of patients with current asthma in the general young adult population. (J Allergy Clin Immunol 2002;110:228-35.)
  • Editor: New York, NY: Mosby, Inc
  • Idioma: Inglés
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