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Expression of tumor necrosis factor-alpha–converting enzyme and tumor necrosis factor-alpha in human myocarditis

Satoh, Mamoru ; Nakamura, Motoyuki ; Satoh, Hidetoshi ; Saitoh, Hidenori ; Segawa, Ikuo ; Hiramori, Katsuhiko

Journal of the American College of Cardiology, 2000-10, Vol.36 (4), p.1288-1294 [Periódico revisado por pares]

New York, NY: Elsevier Inc

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Título:
Expression of tumor necrosis factor-alpha–converting enzyme and tumor necrosis factor-alpha in human myocarditis
Autor: Satoh, Mamoru ; Nakamura, Motoyuki ; Satoh, Hidetoshi ; Saitoh, Hidenori ; Segawa, Ikuo ; Hiramori, Katsuhiko
Assuntos: ADAM Proteins ; ADAM17 Protein ; Adolescent ; Adult ; Aged ; Biological and medical sciences ; Biomarkers ; Biopsy ; Cardiology. Vascular system ; Disease Progression ; DNA Probes - chemistry ; Female ; Heart ; Humans ; Male ; Medical sciences ; Metalloendopeptidases - genetics ; Metalloendopeptidases - metabolism ; Middle Aged ; Myocarditis - metabolism ; Myocarditis - pathology ; Myocarditis. Cardiomyopathies ; Myocardium - metabolism ; Myocardium - pathology ; Prognosis ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Tumor Necrosis Factor-alpha - genetics ; Tumor Necrosis Factor-alpha - metabolism
É parte de: Journal of the American College of Cardiology, 2000-10, Vol.36 (4), p.1288-1294
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: OBJECTIVES We determined whether tumor necrosis factor-alpha–converting enzyme (TACE) is expressed with tumor necrosis factor-alpha (TNF-alpha) in myocarditis. BACKGROUND Tumor necrosis factor-alpha–converting enzyme, which has recently been identified as belonging to the family of metalloproteinase disintegrin proteins, is responsible for the conversion of TNF-alpha precursor to its mature form. METHODS We examined TACE and TNF-alpha expressions in endomyocardial biopsy tissues obtained from 14 patients with myocarditis and five control subjects by using quantitative reverse transcriptase polymerase chain reaction and immunohistochemistry. RESULTS Expression of TNF-alpha and TACE messenger ribonucleic acid (mRNA) was significantly greater in the myocarditis group than in the control group. A positive correlation was found between TNF-alpha and TACE mRNAs (r = 0.83, p < 0.05). Six patients with severe myocarditis underwent repeat biopsies. Although TNF-alpha and TACE mRNAs were expressed at high levels in the initial biopsies, a marked decrease was noted in the repeat biopsies. The immunostainings for TNF-alpha and TACE were positive in the myocytes and interstitial cells of myocardium obtained from patients with myocarditis. Expression of TACE and TNF-alpha mRNAs was greater in the subgroup in New York Heart Association functional class III or IV than in the subgroup in class I or II. Expression of TACE and TNF-alpha mRNA was correlated positively with left ventricular volume (TNF-alpha: r = 0.85; TACE: r = 0.80) and negatively with left ventricular systolic function (TNF-alpha: r = −0.85; TACE: r = −0.85). CONCLUSIONS These findings indicate that the expression of TNF-alpha and TACE may have important implications in the pathogenesis of myocarditis and may influence advanced cardiac dysfunction in myocarditis.
Editor: New York, NY: Elsevier Inc
Idioma: Inglês

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Expression of tumor necrosis factor-alpha–converting enzyme and tumor necrosis factor-alpha in human myocarditis

Satoh, Mamoru ; Nakamura, Motoyuki ; Satoh, Hidetoshi ; Saitoh, Hidenori ; Segawa, Ikuo ; Hiramori, Katsuhiko

New York, NY: Elsevier Inc

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