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The excitatory amino acid glutamate mediates reflexly increased tracheal blood flow and airway submucosal gland secretion

Haxhiu, M.A. ; Chavez, J.C. ; Pichiule, P. ; Erokwu, B. ; Dreshaj, I.A.

Brain research, 2000-11, Vol.883 (1), p.77-86 [Periódico revisado por pares]

London: Elsevier B.V

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Título:
The excitatory amino acid glutamate mediates reflexly increased tracheal blood flow and airway submucosal gland secretion
Autor: Haxhiu, M.A. ; Chavez, J.C. ; Pichiule, P. ; Erokwu, B. ; Dreshaj, I.A.
Assuntos: 6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology ; Airway ; Airway blood flow ; Airway sensory receptor ; Airway submucosal gland ; AMPA/kainate receptor ; Animals ; Autonomic control ; Biological and medical sciences ; Blood Pressure - drug effects ; Dogs ; Female ; Fundamental and applied biological sciences. Psychology ; Glutamic Acid - physiology ; Heart Rate - drug effects ; Injections, Intraventricular ; Male ; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration ; Nucleus ambiguus ; Nucleus tractus solitarii ; Parasympathetic nervous system ; Receptors, AMPA - antagonists & inhibitors ; Receptors, Kainic Acid - antagonists & inhibitors ; Reflex - physiology ; Regional Blood Flow - physiology ; Respiration ; Respiratory Mucosa - drug effects ; Respiratory Mucosa - metabolism ; solitary tract nucleus ; Trachea - blood supply ; Vertebrates: nervous system and sense organs
É parte de: Brain research, 2000-11, Vol.883 (1), p.77-86
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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Descrição: In six decerebrated and in eight α-chloralose anesthetized, paralyzed and mechanically ventilated beagle dogs, we have studied involvement of glutamate and glutamate receptors in transmission of excitatory inputs from the airway sensory receptors to the nucleus tractus solitarius and from this site to airway-related vagal preganglionic cells that regulate the tracheal circulation and the submucosal gland secretion. Stimulation of airway sensory fibers by lung deflation-induced reflex increase in tracheal blood flow and submucosal gland secretion. These responses were diminished by prior administration of AMPA/kainate receptor antagonist CNQX into the fourth ventricle ( n=6). Furthermore, topical application or microinjection of AMPA/kainate receptor blockers, into the region of the ventrolateral medulla, where airway-related vagal preganglionic neurons are located, abolished the reflex changes in tracheal submucosal gland secretion ( n=8); in these dogs mucosal blood flow was not measured). These findings indicate that reflex increase in tracheal blood flow and submucosal gland secretions are mediated mainly via release of glutamate and activation of the AMPA/kainate subtype of glutamate receptors.
Editor: London: Elsevier B.V
Idioma: Inglês

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The excitatory amino acid glutamate mediates reflexly increased tracheal blood flow and airway submucosal gland secretion

Haxhiu, M.A. ; Chavez, J.C. ; Pichiule, P. ; Erokwu, B. ; Dreshaj, I.A.

London: Elsevier B.V

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