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Metabolic labelling and partial characterization of glycophospholipids in pancreatic islet cells

Albor, Amador ; Cáamara, Javier ; Mato, José M. ; Malaisse, Willy J. ; Verde, Isabel Val

Cell biochemistry and function, 1991-04, Vol.9 (2), p.71-77 [Periódico revisado por pares]

Chichester, UK: John Wiley & Sons, Ltd

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Título:
Metabolic labelling and partial characterization of glycophospholipids in pancreatic islet cells
Autor: Albor, Amador ; Cáamara, Javier ; Mato, José M. ; Malaisse, Willy J. ; Verde, Isabel Val
Assuntos: Analytical, structural and metabolic biochemistry ; Animals ; beta-Galactosidase - pharmacology ; Biological and medical sciences ; Cell Line ; cell membranes ; Fundamental and applied biological sciences. Psychology ; Galactose - metabolism ; Glucosamine - metabolism ; Glycolipids - metabolism ; Glycophospholipids ; insulin action ; insulin secretion ; Insulinoma - metabolism ; islet cells ; Islets of Langerhans - drug effects ; Islets of Langerhans - metabolism ; Lipids ; Miscellaneous ; Myristic Acid ; Myristic Acids - metabolism ; Nitrous Acid - pharmacology ; Other biological molecules ; Phosphatidylinositol Diacylglycerol-Lyase ; Phosphoinositide Phospholipase C ; Phosphoric Diester Hydrolases - pharmacology ; Rats ; RINm5F cells ; Structure-Activity Relationship
É parte de: Cell biochemistry and function, 1991-04, Vol.9 (2), p.71-77
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Descrição: Insulin action is thought to be mediated by an inositol‐, glucosamine‐ and galactose‐containing oligosaccharide liberated by phosphodiesterase hydrolysis of a glycosyl‐phosphatidylinositol. This oligosaccharide inhibits insulin biosynthesis and secretion in pancreatic islets. In the present study, two main glycolipids (peak I and II) were resolved by sequential TLC of lipids extracted from islet cells labelled with tritiated glucosamine, galactose or myristate. The two glycolipids displayed comparable sensitivity to β‐galactosidase but differed from one another by their sensitivity to phosphatidylinositol‐specific phospholipase C. Moreover, structural heterogeneity within each peak was suggested by their partial resistance to nitrous acid deamination. These findings support the presence in islet cells of glycolipids similar to those currently considered as a possible postreceptor target for insulin in other cell types.
Editor: Chichester, UK: John Wiley & Sons, Ltd
Idioma: Inglês

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Metabolic labelling and partial characterization of glycophospholipids in pancreatic islet cells

Albor, Amador ; Cáamara, Javier ; Mato, José M. ; Malaisse, Willy J. ; Verde, Isabel Val

Chichester, UK: John Wiley & Sons, Ltd

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