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PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer

XU, Linda L ; STACKHOUSE, Bennett G ; CARTER, Kenneth ; MCLEOD, David G ; MOUL, Judd W ; SOPPETT, Dan ; SRIVASTAVA, Shiv ; FLORENCE, Kim ; WEI ZHANG ; SHANMUGAM, Naga ; SESTERHENN, Iasbell A ; ZHIQIANG ZOU ; SRIKANTAN, Vasantha ; AUGUSTUS, Meena ; ROSCHKE, Viktor

Cancer research (Chicago, Ill.), 2000-12, Vol.60 (23), p.6568-6572 [Periódico revisado por pares]

Philadelphia, PA: American Association for Cancer Research

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Título:
PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer
Autor: XU, Linda L ; STACKHOUSE, Bennett G ; CARTER, Kenneth ; MCLEOD, David G ; MOUL, Judd W ; SOPPETT, Dan ; SRIVASTAVA, Shiv ; FLORENCE, Kim ; WEI ZHANG ; SHANMUGAM, Naga ; SESTERHENN, Iasbell A ; ZHIQIANG ZOU ; SRIKANTAN, Vasantha ; AUGUSTUS, Meena ; ROSCHKE, Viktor
Assuntos: Amino Acid Sequence ; Base Sequence ; Biological and medical sciences ; Epithelial Cells - metabolism ; Gene Expression ; GTP-Binding Proteins - genetics ; GTP-Binding Proteins - metabolism ; Humans ; Male ; Medical sciences ; Molecular Sequence Data ; Neoplasm Proteins ; Nephrology. Urinary tract diseases ; Organ Specificity ; Phylogeny ; Prostate - metabolism ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - metabolism ; PSGR gene ; Receptors, Cell Surface - biosynthesis ; Receptors, Cell Surface - genetics ; Receptors, Odorant - genetics ; Receptors, Odorant - metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Sequence Homology, Amino Acid ; Tumors of the urinary system ; Urinary tract. Prostate gland
É parte de: Cancer research (Chicago, Ill.), 2000-12, Vol.60 (23), p.6568-6572
Notas: ObjectType-Article-2
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Descrição: PSGR, a new prostate tissue-specific gene with homology to the G protein-coupled odorant receptor gene family, has been identified. Here we report the characteristics of the predicted protein sequence of PSGR and its prostate tissue specificity and expression profile in human prostate cancer and matched normal tissues. Using multiple tissue Northern blots from over 50 different tissues, PSGR expression was restricted to human prostate tissues. Paired normal and tumor specimens from 52 primary prostate cancers, obtained by laser capture microdissection or manual microdissection, were analyzed for PSGR expression by semiquantitative and real-time PCR assays. The differential expression of PSGR between normal and tumor tissues was highly significant (P < 0.001), and 32 of 52 (62%) matched prostate specimens exhibited tumor-associated overexpression of PSGR. Of note, there was very little or no expression of PSGR in many normal specimens in comparison with the generally high expression of PSGR seen in matched tumor specimens. In situ hybridization assays showed restricted PSGR expression in the epithelial cells of the normal and tumor tissue sections. Restricted expression of PSGR in prostatic epithelial cells, overexpression of the PSGR in a significant percentage of prostate cancers, and the predicted protein sequence of PSGR with seven transmembrane domains provide a foundation for future studies evaluating the potential of PSGR as a prostate cancer gene expression marker and the utility of PSGR protein as a novel target for developing immunotherapeutic strategies for prostate cancer.
Editor: Philadelphia, PA: American Association for Cancer Research
Idioma: Inglês

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PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer

XU, Linda L ; STACKHOUSE, Bennett G ; CARTER, Kenneth ; MCLEOD, David G ; MOUL, Judd W ; SOPPETT, Dan ; SRIVASTAVA, Shiv ; FLORENCE, Kim ; WEI ZHANG ; SHANMUGAM, Naga ; SESTERHENN, Iasbell A ; ZHIQIANG ZOU ; SRIKANTAN, Vasantha ; AUGUSTUS, Meena ; ROSCHKE, Viktor

Philadelphia, PA: American Association for Cancer Research

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