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The temporal distribution of gene duplication events in a set of highly conserved human gene families

Friedman, Robert ; Hughes, Austin L

Molecular biology and evolution, 2003-01, Vol.20 (1), p.154-161 [Periódico revisado por pares]

United States

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  • Título:
    The temporal distribution of gene duplication events in a set of highly conserved human gene families
  • Autor: Friedman, Robert ; Hughes, Austin L
  • Assuntos: Animals ; Evolution, Molecular ; Gene Duplication ; Genome, Human ; Humans ; Multigene Family ; Phylogeny ; Proteins - analysis ; Proteins - classification ; Proteins - genetics ; Time Factors
  • É parte de: Molecular biology and evolution, 2003-01, Vol.20 (1), p.154-161
  • Notas: ObjectType-Article-2
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  • Descrição: Using a data set of protein translations associated with map positions in the human genome, we identified 1520 mapped highly conserved gene families. By comparing sharing of families between genomic windows, we identified 92 potentially duplicated blocks in the human genome containing 422 duplicated members of these families. Using branching order in the phylogenetic trees, we timed gene duplication events in these families relative to the primate-rodent divergence, the amniote-amphibian divergence, and the deuterostome-protostome divergence. The results showed similar patterns of gene duplication times within duplicated blocks and outside duplicated blocks. Both within and outside duplicated blocks, numerous duplications were timed prior to the deuterostome-protostome divergence, whereas others occurred after the amniote-amphibian divergence. Thus, neither gene duplication in general nor duplication of genomic blocks could be attributed entirely to polyploidization early in vertebrate history. The strongest signal in the data was a tendency for intrachromosomal duplications to be more recent than interchromosomal duplications, consistent with a model whereby tandem duplication-whether of single genes or of genomic blocks-may be followed by eventual separation of duplicates due to chromosomal rearrangements. The rate of separation of tandemly duplicated gene pairs onto separated chromosomes in the human lineage was estimated at 1.7 x 10(-9) per gene-pair per year.
  • Editor: United States
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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