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Pallidal neuronal activity: Implications for models of dystonia

Hutchison, William D. ; Lang, Anthony E. ; Dostrovsky, Jonathan O. ; Lozano, Andres M.

Annals of neurology, 2003-04, Vol.53 (4), p.480-488 [Peer Reviewed Journal]

New York: Wiley Subscription Services, Inc., A Wiley Company

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Title:
Pallidal neuronal activity: Implications for models of dystonia
Author: Hutchison, William D. ; Lang, Anthony E. ; Dostrovsky, Jonathan O. ; Lozano, Andres M.
Subjects: Adolescent ; Adult ; Anticonvulsants - administration & dosage ; Biological and medical sciences ; Child ; Diseases of striated muscles. Neuromuscular diseases ; Dystonia - drug therapy ; Dystonia - physiopathology ; Dystonia - surgery ; Electromyography ; Globus Pallidus - cytology ; Globus Pallidus - physiopathology ; Humans ; Medical sciences ; Microelectrodes ; Middle Aged ; Neurology ; Neurons - physiology ; Parkinson Disease - physiopathology ; Propofol - administration & dosage
Is Part Of: Annals of neurology, 2003-04, Vol.53 (4), p.480-488
Notes: istex:8ABF6B5CFF705BE94E470CD92FBDD4B1B0A90619
Parkinson Society of Canada
ArticleID:ANA10474
ark:/67375/WNG-926TKT9G-3
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Description: Dystonia is a neurological syndrome involving sustained contractions of opposing muscles leading to abnormal movements and postures. Recent studies report abnormally low pallidal neuronal activity in patients with generalized dystonia, suggesting hyperkinetic disorders result from underactive basal ganglia output. We examined this hypothesis in 11 patients with segmental and generalized dystonia undergoing microelectrode exploration of the internal globus pallidus (GPi) before pallidotomy or deep brain stimulation (DBS) implantation. The mean firing rates and firing patterns were compared with those in six patients with Parkinson's disease (PD). In seven patients who underwent surgery under local anesthesia, the mean GPi firing rate was 77Hz, similar to the 74Hz observed in the PD patients. However, in three dystonic patients under propofol anesthesia, GPi mean firing rate was much reduced (31Hz), and the firing pattern was distinguished by long pauses in activity, as reported by others. Low‐dose propofol in one other dystonia patient also seemed to suppress GPi firing. These results indicate that an abnormally low basal ganglia output is not the sine qua non of dystonia. The widely accepted pathophysiological models of dystonia that propose global decreases in basal ganglia output need to be viewed with caution in light of these findings. Ann Neurol 2003
Publisher: New York: Wiley Subscription Services, Inc., A Wiley Company
Language: English

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Pallidal neuronal activity: Implications for models of dystonia

Hutchison, William D. ; Lang, Anthony E. ; Dostrovsky, Jonathan O. ; Lozano, Andres M.

New York: Wiley Subscription Services, Inc., A Wiley Company

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