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Aneuploidy Is Associated with TP53 Expression but not with BRCA1 or TERT Expression in Sporadic Colorectal Cancer

AASA R. SCHJÃ˜LBERG ; OLE PETTER F. CLAUSEN ; ESPEN BURUM-AUENSEN ; PAULA M. DE ANGELIS

Anticancer research, 2009-11, Vol.29 (11), p.4381-4387 [Periódico revisado por pares]

Greece: International Institute of Anticancer Research

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Título:
Aneuploidy Is Associated with TP53 Expression but not with BRCA1 or TERT Expression in Sporadic Colorectal Cancer
Autor: AASA R. SCHJÃ˜LBERG ; OLE PETTER F. CLAUSEN ; ESPEN BURUM-AUENSEN ; PAULA M. DE ANGELIS
Assuntos: Adult ; Aged ; Aged, 80 and over ; Aneuploidy ; Aurora Kinase A ; Aurora Kinase B ; Aurora Kinases ; Biopsy ; BRCA1 Protein - biosynthesis ; BRCA1 Protein - genetics ; Calcium-Binding Proteins - biosynthesis ; Calcium-Binding Proteins - genetics ; Cell Cycle Proteins - biosynthesis ; Cell Cycle Proteins - genetics ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - pathology ; Female ; Humans ; Immunohistochemistry ; Mad2 Proteins ; Male ; Middle Aged ; Protein-Serine-Threonine Kinases - biosynthesis ; Protein-Serine-Threonine Kinases - genetics ; Repressor Proteins - biosynthesis ; Repressor Proteins - genetics ; Telomerase - biosynthesis ; Telomerase - genetics ; Tumor Suppressor Protein p53 - biosynthesis ; Tumor Suppressor Protein p53 - genetics
É parte de: Anticancer research, 2009-11, Vol.29 (11), p.4381-4387
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Background: Defective expression of genes involved in mitotic chromosome segregation (e.g. AURKA, BUB1B), DNA damage response (e.g. TP53, BRCA1), and telomere function (e.g. TERT) may play a role in the development of tumor aneuploidy. Materials and Methods: The levels of TP53, BRCA1 and TERT were assessed in 55 sporadic colorectal tumors and 37 normal mucosas using tissue microarrays and immunohistochemical detection, and their associations with DNA aneuploidy, levels of mitotic spindle proteins AURKA, AURKB, MAD2L1 and BUB1B and clinicopathological parameters were investigated. Results: DNA aneuploidy was associated only with TP53 alterations. BRCA1 expression in tumors was significantly correlated with individual mitotic spindle protein expressions, and TERT and MAD2L1 expressions were moderately correlated in the tumor group, suggesting a putative role for TERT in MAD2L1 regulation. Conclusion: Loss of TP53 function appears to be involved in the development of aneuploidy, but not in the deregulation of mitotic spindle protein function.
Editor: Greece: International Institute of Anticancer Research
Idioma: Inglês

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Aneuploidy Is Associated with TP53 Expression but not with BRCA1 or TERT Expression in Sporadic Colorectal Cancer

AASA R. SCHJÃ˜LBERG ; OLE PETTER F. CLAUSEN ; ESPEN BURUM-AUENSEN ; PAULA M. DE ANGELIS

Greece: International Institute of Anticancer Research

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