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Reactive oxygen species in rostral ventrolateral medulla modulate cardiac sympathetic afferent reflex in rats

Zhong, M.-K ; Gao, J ; Zhang, F ; Xu, B ; Fan, Z.-D ; Wang, W ; Zhu, G.-Q

Acta Physiologica, 2009-12, Vol.197 (4), p.297-304 [Periódico revisado por pares]

Oxford, UK: Oxford, UK : Blackwell Publishing Ltd

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Título:
Reactive oxygen species in rostral ventrolateral medulla modulate cardiac sympathetic afferent reflex in rats
Autor: Zhong, M.-K ; Gao, J ; Zhang, F ; Xu, B ; Fan, Z.-D ; Wang, W ; Zhu, G.-Q
Assuntos: Acetophenones - pharmacology ; Afferent Pathways - drug effects ; Afferent Pathways - physiology ; angiotensin II ; Angiotensin II - pharmacology ; Animals ; Antioxidants - pharmacology ; Autonomic Pathways - drug effects ; Autonomic Pathways - physiology ; Biological and medical sciences ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Capsaicin - pharmacology ; cardiovascular reflex ; Cyclic N-Oxides - pharmacology ; Free Radical Scavengers - pharmacology ; Fundamental and applied biological sciences. Psychology ; Heart - innervation ; Kidney - innervation ; Male ; Medulla Oblongata - cytology ; Medulla Oblongata - drug effects ; Medulla Oblongata - metabolism ; NADPH Oxidases - antagonists & inhibitors ; NADPH Oxidases - metabolism ; Neuroprotective Agents - pharmacology ; Paraventricular Hypothalamic Nucleus - drug effects ; paraventricular nucleus ; Polyethylene Glycols - pharmacology ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; reactive oxygen species ; Reactive Oxygen Species - metabolism ; Reflex - drug effects ; Reflex - physiology ; rostral ventrolateral medulla ; Sensory System Agents - pharmacology ; Spin Labels ; Superoxide Dismutase - antagonists & inhibitors ; Superoxide Dismutase - metabolism ; Superoxide Dismutase - pharmacology ; sympathetic activity ; Sympathetic Nervous System - drug effects ; Sympathetic Nervous System - physiology ; Vasoconstrictor Agents - pharmacology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems
É parte de: Acta Physiologica, 2009-12, Vol.197 (4), p.297-304
Notas: http://dx.doi.org/10.1111/j.1748-1716.2009.02026.x
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ark:/67375/WNG-X90PS4RD-H
ArticleID:APHA2026
The first two authors contributed equally to this work.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The aim of the present study was to investigate whether reactive oxygen species (ROS) in rostral ventrolateral medulla (RVLM) modulate cardiac sympathetic afferent reflex (CSAR) and the enhanced CSAR response caused by microinjection of angiotensin II (Ang II) into the paraventricular nucleus (PVN). Under urethane and α-chloralose anaesthesia, renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) were recorded in sinoaortic-denervated and cervical-vagotomized rats. The CSAR was evaluated by the RSNA response to epicardial application of capsaicin (1.0 nmol). Bilateral RVLM microinjection of tempol (a superoxide anion scavenger) or polyethylene glycol-superoxide dismutase (PEG-SOD, an analogue of endogenous superoxide dismutase) attenuated the CSAR, but did not cause significant change in baseline RSNA and MAP. NAD(P)H oxidase inhibitors apocynin or phenylarsine oxide (PAO) also showed similar effects, but SOD inhibitor diethyldithio-carbamic acid (DETC) enhanced the CSAR and baseline RSNA, and increased the baseline MAP. Bilateral PVN microinjection of Ang II (0.3 nmol) enhanced the CSAR and increased RSNA and MAP, which was inhibited by the pre-treatment with RVLM administration of tempol, PEG-SOD, apocynin or PAO. The pre-treatment with DETC in the RVLM only showed a tendency in potentiating the CSAR response of Ang II in the PVN, but significantly potentiated the RSNA and MAP responses of Ang II. These results suggest that the NAD(P)H oxidase-derived ROS in the RVLM modulate the CSAR. The ROS in the RVLM is necessary for the enhanced CSAR response caused by Ang II in the PVN.
Editor: Oxford, UK: Oxford, UK : Blackwell Publishing Ltd
Idioma: Inglês

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Reactive oxygen species in rostral ventrolateral medulla modulate cardiac sympathetic afferent reflex in rats

Zhong, M.-K ; Gao, J ; Zhang, F ; Xu, B ; Fan, Z.-D ; Wang, W ; Zhu, G.-Q

Oxford, UK: Oxford, UK : Blackwell Publishing Ltd

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