Idioma:

The effect of mirtazapine add on therapy to risperidone in the treatment of schizophrenia: A double-blind randomized placebo-controlled trial

Abbasi, Seyed-Hesameddin ; Behpournia, Haleh ; Ghoreshi, Aboulfazl ; Salehi, Bahman ; Raznahan, Maedeh ; Rezazadeh, Shams-Ali ; Rezaei, Farzin ; Akhondzadeh, Shahin

Schizophrenia research, 2010-02, Vol.116 (2), p.101-106 [Periódico revisado por pares]

Amsterdam: Elsevier B.V

Texto completo disponível

Citações Citado por

Enviar para

Título:
The effect of mirtazapine add on therapy to risperidone in the treatment of schizophrenia: A double-blind randomized placebo-controlled trial
Autor: Abbasi, Seyed-Hesameddin ; Behpournia, Haleh ; Ghoreshi, Aboulfazl ; Salehi, Bahman ; Raznahan, Maedeh ; Rezazadeh, Shams-Ali ; Rezaei, Farzin ; Akhondzadeh, Shahin
Assuntos: 5-HT ; Adult ; Adult and adolescent clinical studies ; Antidepressive Agents, Tricyclic - therapeutic use ; Antipsychotic Agents - therapeutic use ; Biological and medical sciences ; Double-Blind Method ; Female ; Humans ; Male ; Medical sciences ; Mianserin - analogs & derivatives ; Mianserin - therapeutic use ; Middle Aged ; Mirtazapine ; Negative symptoms ; Neuropharmacology ; Pharmacology. Drug treatments ; Prospective Studies ; Psychiatric Status Rating Scales ; Psychiatry ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psycholeptics: tranquillizer, neuroleptic ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychopharmacology ; Psychoses ; Regression Analysis ; Risperidone - therapeutic use ; Schizophrenia ; Schizophrenia - drug therapy ; Treatment Outcome ; Young Adult
É parte de: Schizophrenia research, 2010-02, Vol.116 (2), p.101-106
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-1
ObjectType-Feature-3
content type line 23
Descrição: Abstract It has been reported that mirtazapine would be helpful for treating negative symptoms in schizophrenia. Nevertheless, the results are contradictory so far. This study was designed to investigate the effect of mirtazapine added to risperidone as augmentation therapy in patients with chronic schizophrenia and prominent negative symptoms in a double-blind and randomized clinical trial. Eligible participants in the study were 40 patients with chronic schizophrenia with ages ranging from 19 to 49 years. All patients were inpatients and were in the active phase of the illness, and met DSM-IV-TR criteria for schizophrenia. Patients were allocated in a random fashion 20 to risperidone 6 mg/day plus mirtazapine 30 mg/day and 20 to risperidone 6 mg/day plus placebo. The principal measure of the outcome was Positive and Negative Syndrome Scale (PANSS). The mirtazapine group had significantly greater improvement in the negative symptoms and PANSS total scores over the eight-week trial. Therapy with 30 mg/day of mirtazapine was well tolerated and no clinically important side effects were observed. The present study indicates mirtazapine as a potential combination treatment strategy for chronic schizophrenia particularly for negative symptoms.
Editor: Amsterdam: Elsevier B.V
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

The effect of mirtazapine add on therapy to risperidone in the treatment of schizophrenia: A double-blind randomized placebo-controlled trial

Abbasi, Seyed-Hesameddin ; Behpournia, Haleh ; Ghoreshi, Aboulfazl ; Salehi, Bahman ; Raznahan, Maedeh ; Rezazadeh, Shams-Ali ; Rezaei, Farzin ; Akhondzadeh, Shahin

Amsterdam: Elsevier B.V

Buscando em bases de dados remotas. Favor aguardar.