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Studies on peptides. CV. Synthesis of chicken neurotensin

Yajima, H ; Minamitake, Y ; Funakoshi, S ; Akaji, K ; Oishi, M ; Akazawa, Y ; Segawa, T ; Nakata, Y ; Inoue, A

Chemical and Pharmaceutical Bulletin, 1981/09/25, Vol.29(9), pp.2587-2591 [Periódico revisado por pares]

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Título:
Studies on peptides. CV. Synthesis of chicken neurotensin
Autor: Yajima, H ; Minamitake, Y ; Funakoshi, S ; Akaji, K ; Oishi, M ; Akazawa, Y ; Segawa, T ; Nakata, Y ; Inoue, A
Assuntos: animal physiology ; Animals ; Chickens ; Guinea Pigs ; HPLC of synthetic chicken neurotensin ; In Vitro Techniques ; Neurotensin - chemical synthesis ; Neurotensin - pharmacology ; Rats
É parte de: Chemical and Pharmaceutical Bulletin, 1981/09/25, Vol.29(9), pp.2587-2591
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: A tridecapeptide corresponding to the entire amino acid sequence of chicken neurotensin was synthesized by applying a new deprotecting procedure with trifluoromethanesulfonic acid-thioanisole in combination with a new arginine derivative, Arg (mesitylene-2-sulfonyl). The synthetic avian neurotensin was found to be as active as synthetic bovine neurotensin in terms of contractile activity in isolated guinea-pig ileum and hypotensive effects in rats.
Editor: Japan: The Pharmaceutical Society of Japan
Idioma: Inglês

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