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1,25-Dihydroxyvitamin D3: Short- and Long-Term Effects on Bone and Calcium Metabolism in Patients with Postmenopausal Osteoporosis

Gallagher, J. C. ; Jerpbak, C. M. ; Jee, W. S. S. ; Johnson, K. A. ; DeLuca, H. F. ; Riggs, B. L.

Proceedings of the National Academy of Sciences - PNAS, 1982-05, Vol.79 (10), p.3325-3329 [Revista revisada por pares]

United States: National Academy of Sciences of the United States of America

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  • Título:
    1,25-Dihydroxyvitamin D3: Short- and Long-Term Effects on Bone and Calcium Metabolism in Patients with Postmenopausal Osteoporosis
  • Autor: Gallagher, J. C. ; Jerpbak, C. M. ; Jee, W. S. S. ; Johnson, K. A. ; DeLuca, H. F. ; Riggs, B. L.
  • Materias: Biopsies ; Bone and Bones - metabolism ; Bone formation ; Bone resorption ; Bones ; Calcitriol - therapeutic use ; Calcium ; Calcium - metabolism ; Female ; Homeostasis ; Humans ; Menopause ; Osteoporosis ; Osteoporosis - drug therapy ; Phosphatases ; Placebos ; Postmenopausal osteoporosis ; Space life sciences
  • Es parte de: Proceedings of the National Academy of Sciences - PNAS, 1982-05, Vol.79 (10), p.3325-3329
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descripción: We evaluated the effects of therapy with a small dose (0.5 μ g/day) of 1,25-dihydroxyvitamin D3in 12 previously untreated patients with postmenopausal osteoporosis. Combined radiocalcium kinetic and balance studies showed that at base line, net calcium absorption (mean ± SEM) was low (7± 3%), calcium balance was negative -59± 22 mg/day), and bone resorption rate (297± 40 mg/day) exceeded bone formation rate (239± 36 mg/day). After short-term therapy (6-8 months), calcium absorption was normal (27± 3%, P < 0.001 for difference from base line), calcium balance had improved (+2± 26 mg/day, P < 0.05), and bone resorption rate (195± 35 mg/day, P < 0.01) had decreased more than bone formation rate (197± 26 mg/day, NS). Compared with base-line values, after long-term therapy (2 years) the increased level of calcium absorption was maintained (27± 3%, P < 0.001), but calcium retention declined to a level intermediate (-27± 24 mg/day, NS) between base-line and short-term treatment values, and both bone resorption rate (294± 33 mg/day, NS) and bone formation rate (267± 34 mg/day, NS) increased. Urinary hydroxyproline excretion was lower than before treatment (26.3± 2.0 mg/day) after both short-term (21.1± 1.6 mg/day, P < 0.001) and long-term (22.0± 1.8 mg/day, P < 0.01) treatments. Trabecular bone volume was 11.3± 1.0% at base line and increased to 16.0± 1.2% (P < 0.01) after long-term treatment. By contrast, the eight patients studied before and after 6-8 months of placebo treatment had no significant change in any variable.
  • Editor: United States: National Academy of Sciences of the United States of America
  • Idioma: Inglés
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