Idioma:

A 4-week repeated oral dose toxicity study of fucoidan from the Sporophyll of Undaria pinnatifida in Sprague–Dawley rats

Kim, Kui-Jin ; Lee, Ok-Hwan ; Lee, Hee-Hyun ; Lee, Boo-Yong

Toxicology (Amsterdam), 2010-01, Vol.267 (1), p.154-158 [Periódico revisado por pares]

Kidlington: Elsevier Ireland Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
A 4-week repeated oral dose toxicity study of fucoidan from the Sporophyll of Undaria pinnatifida in Sprague–Dawley rats
Autor: Kim, Kui-Jin ; Lee, Ok-Hwan ; Lee, Hee-Hyun ; Lee, Boo-Yong
Assuntos: Administration, Oral ; Animals ; Anticoagulants - toxicity ; Antineoplastic Agents - toxicity ; Antiviral Agents - toxicity ; Biological and medical sciences ; Biomarkers - blood ; Biomarkers - urine ; Body Weight - drug effects ; Drinking - drug effects ; Eating - drug effects ; Emergency ; Female ; Fibrinolytic Agents - toxicity ; Fucoidan ; Male ; Medical sciences ; Oral toxicity ; Organ Size - drug effects ; Polysaccharides - administration & dosage ; Polysaccharides - toxicity ; Rats ; Rats, Sprague-Dawley ; Safety ; Sulfated polysaccharide ; Toxicity Tests ; Toxicology ; Undaria - chemistry ; Undaria pinnatifida
É parte de: Toxicology (Amsterdam), 2010-01, Vol.267 (1), p.154-158
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Abstract Fucoidan is extracted from brown seaweeds, which can have anti-coagulant, antithrombotic, antitumor, and antiviral activities. However, detailed studies on the toxicology of fucoidan have not been performed. Here we tested the toxicity of fucoidan in Sprague–Dawley rats. Fucoidan (1350 mg/kg bw/day for 4 weeks) did not induce statistically significant differences in groups matched by gender with respect to body weight, ophthalmoscopy, urinalysis, hematology, and histopathology. Fucoidan did not change prothrombin time or activated partial thromboplastin time, indicating an inability to change blood clotting. This study demonstrated that fucoidan is not toxic under this administration paradigm.
Editor: Kidlington: Elsevier Ireland Ltd
Idioma: Inglês

Links

Voltar para lista de resultados

Anterior Resultado 6 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

A 4-week repeated oral dose toxicity study of fucoidan from the Sporophyll of Undaria pinnatifida in Sprague–Dawley rats

Kim, Kui-Jin ; Lee, Ok-Hwan ; Lee, Hee-Hyun ; Lee, Boo-Yong

Kidlington: Elsevier Ireland Ltd

Buscando em bases de dados remotas. Favor aguardar.