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A randomized trial of coenzyme Q10 in mitochondrial disorders

Glover, Elisa I. ; Martin, Joan ; Maher, Amy ; Thornhill, Rebecca E. ; Moran, Gerald R. ; Tarnopolsky, Mark A.

Muscle & nerve, 2010-11, Vol.42 (5), p.739-748 [Periódico revisado por pares]

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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Título:
A randomized trial of coenzyme Q10 in mitochondrial disorders
Autor: Glover, Elisa I. ; Martin, Joan ; Maher, Amy ; Thornhill, Rebecca E. ; Moran, Gerald R. ; Tarnopolsky, Mark A.
Assuntos: Absorptiometry, Photon ; Activities of Daily Living ; Adult ; Anaerobic Threshold - drug effects ; Antioxidants - metabolism ; Antioxidants - therapeutic use ; Biological and medical sciences ; Body Composition - physiology ; Brain Chemistry - drug effects ; Choline - metabolism ; coenzyme Q10 ; Cross-Over Studies ; Diseases of striated muscles. Neuromuscular diseases ; Double-Blind Method ; Drug therapy ; Exercise ; Exercise Test ; Female ; Forearm - physiology ; Hemodynamics - drug effects ; Humans ; Isometric Contraction - physiology ; Lactic Acid - blood ; Magnetic Resonance Spectroscopy ; Male ; Medical sciences ; MELAS ; Middle Aged ; mitochondrial cocktail ; Mitochondrial Diseases - drug therapy ; mitochondrial myopathy ; Muscle ; Muscle Fatigue - physiology ; Neurology ; Oxidative Stress - physiology ; oxygen consumption ; Oxygen Consumption - physiology ; Pharmacology. Drug treatments ; Quality of Life ; Spectroscopy, Near-Infrared ; Ubiquinone - analogs & derivatives ; Ubiquinone - blood ; Ubiquinone - therapeutic use
É parte de: Muscle & nerve, 2010-11, Vol.42 (5), p.739-748
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Descrição: Case reports and open‐label studies suggest that coenzyme Q10 (CoQ10) treatment may have beneficial effects in mitochondrial disease patients; however, controlled trials are warranted to clinically prove its effectiveness. Thirty patients with mitochondrial cytopathy received 1200 mg/day CoQ10 for 60 days in a randomized, double‐blind, cross‐over trial. Blood lactate, urinary markers of oxidative stress, body composition, activities of daily living, quality of life, forearm handgrip strength and oxygen desaturation, cycle exercise cardiorespiratory variables, and brain metabolites were measured. CoQ10 treatment attenuated the rise in lactate after cycle ergometry, increased (∽1.93 ml) VO2/kg lean mass after 5 minutes of cycling (P < 0.005), and decreased gray matter choline‐containing compounds (P < 0.05). Sixty days of moderate‐ to high‐dose CoQ10 treatment had minor effects on cycle exercise aerobic capacity and post‐exercise lactate but did not affect other clinically relevant variables such as strength or resting lactate. Muscle Nerve, 2010
Editor: Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Idioma: Inglês

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A randomized trial of coenzyme Q10 in mitochondrial disorders

Glover, Elisa I. ; Martin, Joan ; Maher, Amy ; Thornhill, Rebecca E. ; Moran, Gerald R. ; Tarnopolsky, Mark A.

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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