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1,25-Dihydroxycholecalciferol analogs cannot replace vitamin D in normocalcemic male rats

UHLAND-SMITH, A ; DELUCA, H. F

The Journal of nutrition, 1993-11, Vol.123 (11), p.1777-1785 [Periódico revisado por pares]

Bethesda, MD: American Society for Nutritional Sciences

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Título:
1,25-Dihydroxycholecalciferol analogs cannot replace vitamin D in normocalcemic male rats
Autor: UHLAND-SMITH, A ; DELUCA, H. F
Assuntos: absorcion ; absorcion digestiva ; absorption ; absorption digestive ; Animals ; Animals, Newborn ; Biological and medical sciences ; Biological Transport ; blood serum ; Bone and Bones - chemistry ; bones ; calcio ; Calcitriol - blood ; Calcitriol - pharmacology ; calcium ; Calcium - blood ; Calcium - pharmacology ; crecimiento ; croissance ; Development. Metamorphosis. Moult. Ageing ; Diet ; dieta ; digestive absorption ; esteroles ; experimentacion ; experimentation ; Female ; fisiologia de la nutricion ; Fundamental and applied biological sciences. Psychology ; growth ; Growth - drug effects ; huesos ; Intestine, Small - metabolism ; Kidney - chemistry ; kidneys ; maduracion ; Male ; maturation ; nutrition physiology ; Physical growth ; physiologie de la nutrition ; rat ; rata ; Rats ; Rats, Inbred Strains ; Receptors, Calcitriol - analysis ; regime alimentaire ; rein ; rinones ; Rodents ; serum sanguin ; Space life sciences ; sterol ; sterols ; suero sanguineo ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - pharmacology ; Vitamin D Deficiency - metabolism ; vitamina d ; vitamine d
É parte de: The Journal of nutrition, 1993-11, Vol.123 (11), p.1777-1785
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Descrição: A possible role of vitamin D in the growth and development of rats was investigated. Impaired development was observed in normocalcemic, vitamin D-deficient male and female rats, as revealed by low intestinal calcium transport, low renal vitamin D receptor levels and poor bone mineralization. Analogs of 1,25-dihydroxycholecalciferol, possessing reduced calcium-mobilizing activity in intestine and bone but retaining differentiation activity in cultured cells, were unable to support normal development of normocalcemic, vitamin D-deficient male rats. These results suggest that either the calcium-mobilizing activity alone or both the calcium-mobilizing activity and differentiating activity of vitamin D are required for normal development or that the analogs are inactive in vivo. We also demonstrated sex-related differences in intestinal calcium transport, renal vitamin D receptor regulation and bone mineralization that were independent of vitamin D status.
Editor: Bethesda, MD: American Society for Nutritional Sciences
Idioma: Inglês

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1,25-Dihydroxycholecalciferol analogs cannot replace vitamin D in normocalcemic male rats

UHLAND-SMITH, A ; DELUCA, H. F

Bethesda, MD: American Society for Nutritional Sciences

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