skip to main content
Idioma:
Primo Search
Clear Search Box
Search in: Busca Geral
Busca Avançada
Busca por Índices
Tipo de recurso Mostra resultados com: Mostra resultados com: Índice

Choline acetyltransferase activity and total protein content in selected optic areas of the rat after complete light-deprivation during CNS development

Maletta, G J ; Timiras, P S

Journal of neurochemistry, 1968-08, Vol.15 (8), p.787-793 [Periódico revisado por pares]

England

Sem texto completo

Citações Citado por
  • Título:
    Choline acetyltransferase activity and total protein content in selected optic areas of the rat after complete light-deprivation during CNS development
  • Autor: Maletta, G J ; Timiras, P S
  • Assuntos: Animals ; Animals, Newborn ; Choline O-Acetyltransferase - metabolism ; Gene Expression Regulation, Developmental - physiology ; Male ; Proteins - metabolism ; Rats ; Rats, Long-Evans ; Sensory Deprivation - physiology ; Vision, Ocular ; Visual Pathways - growth & development ; Visual Pathways - metabolism
  • É parte de: Journal of neurochemistry, 1968-08, Vol.15 (8), p.787-793
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Choline acetyltransferase (acetyl-CoA: choline O-acetyltransferase, I.U.B. 2.3.1.6) activity and total protein content in visual and extra-visual areas were compared in normal Long-Evans rats and in rats subjected to complete light-deprivation for 21 days from birth. The enzyme activity and the protein content in the superior colliculi, lateral geniculate bodies and visual cortex, as well as in the sensory-motor cortex, hypothalamus, brain stem and cerebellum, were measured in both mothers and progeny. By means of a radiochemical technique modified in this laboratory, a significant decline of ChAc activity was observed in the lateral geniculate bodies and superior colliculi, with no significant decline in the visual cortex of the experimental progeny. Total protein content, measured colorimetrically, was significantly decreased in the superior colliculi of the progeny. The biochemical data obtained from all other brain areas in the experimental animals (progeny and mothers) and controls demonstrated no marked differences. The enzymic alterations observed in the cholinergic system of progeny after complete light-deprivation during this critical period of CNS development can be specifically correlated with decreased functional maturation of the visual system. If it is accepted that ACh is a neuro-transmitter in some parts of the visual pathway, the data presented here suggest that complete light-deprivation from birth to 21 days of age in the rat has an effect on a biochemical system involved in synaptic transmission.
  • Editor: England
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.