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Studies on Peptides. CXXXIII. : Synthesis and Biological Activity of Galanin, a Novel Porcine Intestinal Polypeptide

YAJIMA, HARUAKI ; FUTAKI, SHIROH ; FUJII, NOBUTAKA ; AKAJI, KENICHI ; FUNAKOSHI, SUSUMU ; SAKURAI, MITSUYA ; KATAKURA, SHINICHI ; INOUE, KAZUTOMO ; HOSOTANI, RYO ; TOBE, TAKAYOSHI ; SEGAWA, TOMIO ; INOUE, ATSUKO ; TAKEMOTO, KAZUHIKO ; MUTT, VIKTOR

Chemical and Pharmaceutical Bulletin, 1986/02/25, Vol.34(2), pp.528-539 [Periódico revisado por pares]

Tokyo: The Pharmaceutical Society of Japan

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Título:
Studies on Peptides. CXXXIII. : Synthesis and Biological Activity of Galanin, a Novel Porcine Intestinal Polypeptide
Autor: YAJIMA, HARUAKI ; FUTAKI, SHIROH ; FUJII, NOBUTAKA ; AKAJI, KENICHI ; FUNAKOSHI, SUSUMU ; SAKURAI, MITSUYA ; KATAKURA, SHINICHI ; INOUE, KAZUTOMO ; HOSOTANI, RYO ; TOBE, TAKAYOSHI ; SEGAWA, TOMIO ; INOUE, ATSUKO ; TAKEMOTO, KAZUHIKO ; MUTT, VIKTOR
Assuntos: Animals ; Chemistry ; Exact sciences and technology ; Galanin ; Gastrointestinal Hormones - chemical synthesis ; Gastrointestinal Hormones - pharmacology ; hyperglycemic activity ; In Vitro Techniques ; intestine ; Muscle Contraction - drug effects ; Muscle, Smooth - drug effects ; Organic chemistry ; peptide synthesis ; Peptides ; Peptides - chemical synthesis ; Peptides - pharmacology ; pigs ; Preparations and properties ; Rats ; Swine
É parte de: Chemical and Pharmaceutical Bulletin, 1986/02/25, Vol.34(2), pp.528-539
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: A new porcine gastrointestinal 29-residue peptide, galanin, was synthesized in a satisfactory yield by assembling seven peptide fragments followed by deprotection with 1 M trifluoromethane-sulfonic acid-thioanisole in trifluoroacetic acid. Nin-Mesitylenesulfonyltryptophan was employed to suppress indole alkylation during Na-deprotection. β-Cycloheptylaspartate was employed to suppress base-catalyzed succinimide formation. The synthetic peptide exhibited a powerful contractile activity on rat ileum, but not on guinea pig ileum and caused sustained hyperglycemia in dogs.
Editor: Tokyo: The Pharmaceutical Society of Japan
Idioma: Inglês

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