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Developmental and hormonal regulation of the major form of hepatic glutathione S-transferase in male mice

Hatayama, Ichiro ; Satoh, Kimihiko ; Sato, Kiyomi

Biochemical and biophysical research communications, 1986-10, Vol.140 (2), p.581-588 [Periódico revisado por pares]

San Diego, CA: Elsevier Inc

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Título:
Developmental and hormonal regulation of the major form of hepatic glutathione S-transferase in male mice
Autor: Hatayama, Ichiro ; Satoh, Kimihiko ; Sato, Kiyomi
Assuntos: Aging - metabolism ; Animals ; Applied sciences ; Castration ; Exact sciences and technology ; Female ; Glutathione Transferase - classification ; Glutathione Transferase - metabolism ; Liver - enzymology ; Male ; Mice ; Other techniques and industries ; Rats ; Sex Factors ; Sexual Maturation ; Species Specificity ; Testosterone - physiology
É parte de: Biochemical and biophysical research communications, 1986-10, Vol.140 (2), p.581-588
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Among three forms of mouse hepatic glutathione S-transferase, the II form, which is immunologically related to rat 7-7 form, was the major form in adult male mice of all the five strains examined and the levels (about 5.0 mg/g of liver) were approximately ten-fold higher than those of females. This form markedly increased at puberty in male mice, whereas no change was observed in females. By castration, the levels in males decreased to those in females, while those in females increased to those in adult males by administration of testosterone. These results indicate that the expression of II form in mouse liver is regulated developmentally by testosterone, and this protein could be a useful marker for the male mouse.
Editor: San Diego, CA: Elsevier Inc
Idioma: Inglês

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Developmental and hormonal regulation of the major form of hepatic glutathione S-transferase in male mice

Hatayama, Ichiro ; Satoh, Kimihiko ; Sato, Kiyomi

San Diego, CA: Elsevier Inc

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