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Age-related changes in composition of transcription factor, AP-1 complex in the rat brain

Asanuma, Masato ; Kondo, Yoichi ; Nishibayashi, Sakiko ; Iwata, Emi ; Nakanishi, Tohru ; Ogawa, Norio

Neuroscience letters, 1995-12, Vol.201 (2), p.127-130 [Periódico revisado por pares]

Shannon: Elsevier Ireland Ltd

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Título:
Age-related changes in composition of transcription factor, AP-1 complex in the rat brain
Autor: Asanuma, Masato ; Kondo, Yoichi ; Nishibayashi, Sakiko ; Iwata, Emi ; Nakanishi, Tohru ; Ogawa, Norio
Assuntos: Activator protein-1 (AP-1) ; Aging ; Aging - metabolism ; Animals ; Base Sequence ; Biological and medical sciences ; Brain Chemistry - physiology ; Composition of AP-1 ; Development. Senescence. Regeneration. Transplantation ; DNA Probes ; Electrophoresis, Polyacrylamide Gel ; Electrophoretic mobility-shift assay ; Fos-June heterodimer ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation - physiology ; Genes, fos - physiology ; Genes, jun - physiology ; Hippocampus - metabolism ; Jun-Jun homodimer ; Male ; Molecular Sequence Data ; Rat brain ; Rats ; Rats, Inbred F344 ; Transcription Factor AP-1 - chemistry ; Transcription Factor AP-1 - metabolism ; Vertebrates: nervous system and sense organs
É parte de: Neuroscience letters, 1995-12, Vol.201 (2), p.127-130
Notas: ObjectType-Article-2
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Descrição: We examined age-related changes in composition of transcription factor, activator protein-1 (AP-1) which binds to TPA responsive element (TRE) in the non-stimulated rat brain, using electrophoretic mobility-shift assay with immunodepletion/supershift assay. The total TRE-binding activity in the frontal cortex and the hippocampus of the aged rats markedly decreased to 66% and 43%, respectively, and TRE-bindings of AP-1 in both regions also decreased to 82% and 66%, respectively, with aging. Jun-Jun dimers accounted for approximately half of the total TRE-bindings and 80–90% of the AP-1 bindings, while there were fewer Fos-Jun dimers, in both examined regions of the non-stimulated adult. The proportion of active Fos-Jun heterodimers in the frontal cortex increased to up to half of the AP-1 bindings in the aged rats, indicating that cortical AP-1-related transcription may increase with aging even under the non-stimulated condition. In the hippocampus, inactive Jun-Jun homodimers became predominant in AP-1 with aging. This regional diversity of age-related changes in the composition of AP-1 in the brain may be related to changes or dysfunction in neuronal signal transduction in the aged.
Editor: Shannon: Elsevier Ireland Ltd
Idioma: Inglês

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Age-related changes in composition of transcription factor, AP-1 complex in the rat brain

Asanuma, Masato ; Kondo, Yoichi ; Nishibayashi, Sakiko ; Iwata, Emi ; Nakanishi, Tohru ; Ogawa, Norio

Shannon: Elsevier Ireland Ltd

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