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Grafting Genetically Modified Cells to the Damaged Brain: Restorative Effects of NGF Expression

Rosenberg, Michael B. ; Friedmann, Theodore ; Robertson, Robin C. ; Tuszynski, Mark ; Wolff, Jon A. ; Breakefield, Xandra O. ; Gage, Fred H.

Science (American Association for the Advancement of Science), 1988-12, Vol.242 (4885), p.1575-1578 [Periódico revisado por pares]

Washington, DC: The American Association for the Advancement of Science

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Título:
Grafting Genetically Modified Cells to the Damaged Brain: Restorative Effects of NGF Expression
Autor: Rosenberg, Michael B. ; Friedmann, Theodore ; Robertson, Robin C. ; Tuszynski, Mark ; Wolff, Jon A. ; Breakefield, Xandra O. ; Gage, Fred H.
Assuntos: Acetylcholinesterase - metabolism ; Animals ; Biological and medical sciences ; Brain ; Brain - cytology ; Brain - enzymology ; Brain - pathology ; Cell lines ; Cell Survival ; Central nervous system ; Cholinergic mechanisms ; Cholinergics ; DNA - genetics ; Fibroblasts ; Fibroblasts - metabolism ; Fibroblasts - transplantation ; Fornix ; Fundamental and applied biological sciences. Psychology ; Genetic Vectors ; Histocytochemistry ; Isolated neuron and nerve. Neuroglia ; Lesions ; Moloney murine leukemia virus - genetics ; Nerve growth factor ; Nerve Growth Factors - genetics ; Nerve Growth Factors - physiology ; Neurons ; Organ transplantation ; Rats ; Septum ; Tissue grafting ; Tissue transplantation ; Transgenes ; Transplantation ; Transplantation of organs, tissues, etc ; Vertebrates: nervous system and sense organs
É parte de: Science (American Association for the Advancement of Science), 1988-12, Vol.242 (4885), p.1575-1578
Notas: ObjectType-Article-2
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Descrição: Fibroblasts were genetically modified to secrete nerve growth factor (NGF) by infection with a retroviral vector and then implanted into the brains of rats that had surgical lesions of the fimbria-fornix. The grafted cells survived and produced sufficient NGF to prevent the degeneration of cholinergic neurons that would die without treatment. In addition, the protected cholinergic cells sprouted axons that projected in the direction of the cellular source of NGF. These results indicate that a combination of gene transfer and intracerebral grafting may provide an effective treatment for some disorders of the central nervous system.
Editor: Washington, DC: The American Association for the Advancement of Science
Idioma: Inglês

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Grafting Genetically Modified Cells to the Damaged Brain: Restorative Effects of NGF Expression

Rosenberg, Michael B. ; Friedmann, Theodore ; Robertson, Robin C. ; Tuszynski, Mark ; Wolff, Jon A. ; Breakefield, Xandra O. ; Gage, Fred H.

Washington, DC: The American Association for the Advancement of Science

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