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Interaction of halothane with α- and β- adrenoceptor stimulations in rat myocardium

HANOUZ, J.-L ; RIOU, B ; MASSIAS, L ; LECARPENTIER, Y ; CORIAT, P

Anesthesiology (Philadelphia), 1997, Vol.86 (1), p.147-159 [Peer Reviewed Journal]

Hagerstown, MD: Lippincott

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  • Title:
    Interaction of halothane with α- and β- adrenoceptor stimulations in rat myocardium
  • Author: HANOUZ, J.-L ; RIOU, B ; MASSIAS, L ; LECARPENTIER, Y ; CORIAT, P
  • Subjects: Anesthetics, Inhalation - pharmacology ; Anesthetics. Neuromuscular blocking agents ; Animals ; Biological and medical sciences ; Calcium - physiology ; Halothane - pharmacology ; Heart - drug effects ; In Vitro Techniques ; Isoproterenol - pharmacology ; Male ; Medical sciences ; Myocardial Contraction - drug effects ; Neuropharmacology ; Pharmacology. Drug treatments ; Phenylephrine - pharmacology ; Rats ; Rats, Wistar ; Receptors, Adrenergic, alpha - drug effects ; Receptors, Adrenergic, beta - drug effects
  • Is Part Of: Anesthesiology (Philadelphia), 1997, Vol.86 (1), p.147-159
  • Notes: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Description: Halothane induces negative inotropic and lusitropic effects in myocardium. It has been suggested that halothane potentiates beta-adrenoceptor stimulation. However, its effects on the inotropic response to alpha-adrenoceptor stimulation and its effects on the lusitropic effects of alpha- and beta-adrenoceptor stimulation are unknown. The effects of halothane (0.5 and 1 minimum alveolar concentration [MAC]) on the inotropic responses induced by phenylephrine (10(-8) to 10(-4) M) and isoproterenol (10(-8) to 10(-4) M) were studied in rat left ventricular papillary muscles in vitro (in Krebs-Henseleit solution at 29 degrees C, pH 7.40, with 0.5 mM calcium and stimulation frequency at 12 pulses/min). The lusitropic effects were studied in isotonic (R1) and isometric (R2) conditions. One MAC halothane induced a negative inotropic effect (54 +/- 3%, P < 0.05), increased R1 (109 +/- 3%, P < 0.05), and decreased R2 (88 +/- 2%, P < 0.05). In control groups, phenylephrine (137 +/- 7%, P > 0.05) and isoproterenol (162 +/- 6%, P < 0.05) induced a positive inotropic effect. Halothane did not significantly modify the positive inotropic effect of calcium, suggesting that it did not modify the inotropic reserve of papillary muscles. In contrast, 1 MAC halothane enhanced the positive inotropic effects of phenylephrine (237 +/- 19%, P < 0.05) and isoproterenol (205 +/- 11%, P < 0.05). Halothane did not modify the lusitropic effect of phenylephrine under high or low load. In contrast, 1 MAC halothane impaired the positive lusitropic effect of isoproterenol under low load (P < 0.05), whereas it did not modify the positive lusitropic effect of isoproterenol under high load. At clinically relevant concentrations, halothane potentiated the positive inotropic effects of both alpha- and beta-adrenoceptor stimulation. Furthermore, halothane alters the positive lusitropic-effect of beta-adrenoceptor stimulation under low load.
  • Publisher: Hagerstown, MD: Lippincott
  • Language: English
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