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Genetics and Developmental Psychopathology: 2. The Main Effects of Genes and Environment on Behavioral Problems in the Virginia Twin Study of Adolescent Behavioral Development

Eaves, Lindon J. ; Silberg, Judy L. ; Meyer, Joanne M. ; Maes, Hermine H. ; Simonoff, Emily ; Pickles, Andrew ; Rutter, Michael ; Reynolds, Chandra A. ; Heath, Andrew C. ; Truett, Kimberly R. ; Neale, Michael C. ; Erikson, Marilyn T. ; Loeber, Rolf ; Hewitt, John K.

Journal of child psychology and psychiatry, 1997-11, Vol.38 (8), p.965-980 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
Genetics and Developmental Psychopathology: 2. The Main Effects of Genes and Environment on Behavioral Problems in the Virginia Twin Study of Adolescent Behavioral Development
Autor: Eaves, Lindon J. ; Silberg, Judy L. ; Meyer, Joanne M. ; Maes, Hermine H. ; Simonoff, Emily ; Pickles, Andrew ; Rutter, Michael ; Reynolds, Chandra A. ; Heath, Andrew C. ; Truett, Kimberly R. ; Neale, Michael C. ; Erikson, Marilyn T. ; Loeber, Rolf ; Hewitt, John K.
Assuntos: adolescence ; Adolescent ; Adult and adolescent clinical studies ; Anxiety Disorders - diagnosis ; Anxiety Disorders - epidemiology ; Anxiety Disorders - genetics ; attention deficit disorder ; Attention Deficit Disorder with Hyperactivity - diagnosis ; Attention Deficit Disorder with Hyperactivity - epidemiology ; Attention Deficit Disorder with Hyperactivity - genetics ; Attention deficit hyperactivity disorder ; Biological and medical sciences ; Child ; Child clinical studies ; Child psychology ; Cohort Studies ; Comorbidity ; Conduct Disorder - diagnosis ; Conduct Disorder - epidemiology ; Conduct Disorder - genetics ; Cross-Sectional Studies ; Depressive Disorder - diagnosis ; Depressive Disorder - epidemiology ; Depressive Disorder - genetics ; Diseases in Twins - diagnosis ; Diseases in Twins - epidemiology ; Diseases in Twins - genetics ; Environmental-Genetic factors ; Externalizing disorder ; Family ; Female ; Genetics ; Genetics, Behavioral ; Health Surveys ; Humans ; Hyperactivity ; internalizing disorder ; Longitudinal Studies ; Male ; Medical sciences ; Mental Disorders - diagnosis ; Mental Disorders - epidemiology ; Mental Disorders - genetics ; Miscellaneous ; Parents - psychology ; Psychology, Adolescent ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology ; Psychopathology. Psychiatry ; Risk Factors ; Social Environment ; Twins ; Virginia - epidemiology
É parte de: Journal of child psychology and psychiatry, 1997-11, Vol.38 (8), p.965-980
Notas: ark:/67375/WNG-N6056T94-F
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ArticleID:JCPP965
ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Little is known about the contribution of genetic and environmental factors to risk for juvenile psychopathology. The Virginia Twin Study of Adolescent Behavioral Development allows these contributions to be estimated. A population‐based, unselected sample of 1412 Caucasian twin pairs aged 8–16 years was ascertained through Virginia schools. Assessment of the children involved semi‐structured face‐to‐face interviews with both twins and both parents using the Child and Adolescent Psychiatric Assessment (CAPA). Self‐report questionnaires were also completed by parents, children, and teachers. Measures assessed DSM‐III‐R symptoms of Attention Deficit Hyperactivity Disorder (ADHD), Conduct Disorder, Oppositional Defiant Disorder, Overanxious Disorder, Separation Anxiety, and Depressive Disorder. Factorially derived questionnaire scales were also extracted. Scores were normalized and standardized by age and sex. Maximum likelihood methods were used to estimate contributions of additive and nonadditive genetic effects, the shared and unique environment, and sibling imitation or contrast effects. Estimates were tested for heterogeneity over sexes. Generally, monozygotic (MZ) twins correlated more highly than dizygotic (DZ) twins, parental ratings more than child ratings, and questionnaire scales more highly than interviews. DZ correlations were very low for measures of ADHD and DZ variances were greater than MZ variances for these variables. Correlations sometimes differed between sexes but those for boy‐girl pairs were usually similar to those for like‐sex pairs. Most of the measures showed small to moderate additive genetic effects and moderate to large effects of the unique individual environment. Measures of ADHD and related constructs showed marked sibling contrast effects. Some measures of oppositional behavior and conduct disorder showed shared environmental effects. There were marked sex differences in the genetic contribution to separation anxiety, otherwise similar genetic effects appear to be expressed in boys and girls. Effects of rater biases on the genetic analysis are considered. The study supports a widespread influence of genetic factors on risk to adolescent psychopathology and suggests that the contribution of different types of social influence may vary consistently across domains of measurement.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

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Genetics and Developmental Psychopathology: 2. The Main Effects of Genes and Environment on Behavioral Problems in the Virginia Twin Study of Adolescent Behavioral Development

Eaves, Lindon J. ; Silberg, Judy L. ; Meyer, Joanne M. ; Maes, Hermine H. ; Simonoff, Emily ; Pickles, Andrew ; Rutter, Michael ; Reynolds, Chandra A. ; Heath, Andrew C. ; Truett, Kimberly R. ; Neale, Michael C. ; Erikson, Marilyn T. ; Loeber, Rolf ; Hewitt, John K.

Oxford, UK: Blackwell Publishing Ltd

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